Evidence map›Paper›PMID 32554974›Full record

ArticleDementia and geriatric cognitive disorders2020

New Delirium Severity Indicators: Generation and Internal Validation in the Better Assessment of Illness (BASIL) Study.

Sarinnapha M Vasunilashorn, Dena Schulman-Green, Douglas Tommet, Tamara G Fong, Tammy T Hshieh, Edward R Marcantonio, Eran D Metzger, Eva M Schmitt, Patricia A Tabloski, Thomas G Travison and 5 more

Abstract read
In one paragraph

Article in Dementia and geriatric cognitive disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  5. Domains of delirium severity in Alzheimer's disease and related dementias.Journal of the American Geriatrics Society · 2022
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sarinnapha M VasunilashornHarvard Medical School, Boston, Massachusetts, USA, svasunil@bidmc.harvard.edu.
Dena Schulman-GreenYale University School of Nursing, New Haven, Connecticut, USA.
Douglas TommetDepartment of Psychiatry and Human Behavior, Brown University Warren Alpert Medical School, Providence, Rhode Island, USA.
Tamara G FongHarvard Medical School, Boston, Massachusetts, USA.
Tammy T HshiehHarvard Medical School, Boston, Massachusetts, USA.
Edward R MarcantonioHarvard Medical School, Boston, Massachusetts, USA.
Eran D MetzgerHarvard Medical School, Boston, Massachusetts, USA.
Eva M SchmittAging Brain Center, Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA.
Patricia A TabloskiWilliam F. Connell School of Nursing at Boston College, Boston, Massachusetts, USA.
Thomas G TravisonHarvard Medical School, Boston, Massachusetts, USA.
Yun GouAging Brain Center, Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA.
Benjamin HelfandUniversity of Massachusetts Medical School, Worcester, Massachusetts, USA.
Sharon K InouyeHarvard Medical School, Boston, Massachusetts, USA.
Richard N JonesDepartment of Psychiatry and Human Behavior, Brown University Warren Alpert Medical School, Providence, Rhode Island, USA.
the BASIL Study Team

Funding

The Role of Inflammation in the Pathophysiology of Delirium and its Associated Long-Term Cognitive DeclineP01AG031720 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI TRAVISON, THOMAS GLENN · 2010 to 2022
$26.7M
READI-SET-GO: Researching Efficient Approaches to Delirium Identification - Sustaining Effective Translation to create Gero-friendly OrganizationsR01AG030618 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI DONNA Marie FICK, EDWARD R MARCANTONIO · 2008 to 2026
$7.9M
Development and Validation of a Delirium Severity ToolkitR01AG044518 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI INOUYE, SHARON K., JONES, RICHARD N · 2014 to 2024
$7.3M
Supplement to Network for Investigation of Delirium across the U.S (NIDUS)R24AG054259 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI INOUYE, SHARON K. · 2016 to 2020
$4.3M
Mid-Career Mentoring Award for Patient-Oriented Research in AgingK24AG035075 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MARCANTONIO, EDWARD R · 2010 to 2021
$1.9M
K07 Leadership GrantK07AG041835 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI INOUYE, SHARON K. · 2013 to 2017
$656k
Shared Pathophysiology of Postoperative Delirium and Alzheimer’s Disease and Related DementiasK01AG057836 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI VASUNILASHORN, SARINNAPHA · 2018 to 2022
$565k
Genetic and Neuroinflammatory Mechanisms of Delirium and Alzheimer’s Disease and Related DementiasR03AG061582 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI VASUNILASHORN, SARINNAPHA · 2019 to 2020
$175k
NIA NIH HHS K01 AG057836NIA NIH HHS K07 AG041835NIA NIH HHS K24 AG035075NIA NIH HHS P01 AG031720NIA NIH HHS R01 AG030618NIA NIH HHS R01 AG044518NIA NIH HHS R03 AG061582NIA NIH HHS R24 AG054259
6 · The paper itself

Abstract

backgroundDelirium is a common and preventable geriatric syndrome. Moving beyond the binary classification of delirium present/absent, delirium severity represents a potentially important outcome for evaluating preventive and treatment interventions and tracking the course of patients. Although several delirium severity assessment tools currently exist, most have been developed in the absence of advanced measurement methodology and have not been evaluated with rigorous validation studies.

objectiveWe aimed to report our development of new delirium severity items and the results of item reduction and selection activities guided by psychometric analysis of data derived from a field study.

methodsBuilding on our literature review of delirium instruments and expert panel process to identify domains of delirium severity, we adapted items from existing delirium severity instruments and generated new items. We then fielded these items among a sample of 352 older hospitalized patients.

resultsWe used an expert panel process and psychometric data analysis techniques to narrow a set of 303 potential items to 17 items for use in a new delirium severity instrument. The 17-item set demonstrated good internal validity and favorable psychometric characteristics relative to comparator instruments, including the Confusion Assessment Method - Severity (CAM-S) score, the Delirium Rating Scale Revised 98, and the Memorial Delirium Assessment Scale.

conclusionWe more fully conceptualized delirium severity and identified characteristics of an ideal delirium severity instrument. These characteristics include an instrument that is relatively quick to administer, is easy to use by raters with minimal training, and provides a severity rating with good content validity, high internal consistency reliability, and broad domain coverage across delirium symptoms. We anticipate these characteristics to be represented in the subsequent development of our final delirium severity instrument.

Indexed as

AgedDeliriumFemaleGeriatric AssessmentHospitalizationHumansMalePsychometricsReproducibility of ResultsSeverity of Illness IndexDeliriumDelirium severityPsychometrics

Identifiers

PMID32554974
PMCPMC7484102

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.