Evidence map›Paper›PMID 32554863›Full record

ArticleAging2020

Multi-omics network analysis reveals distinct stages in the human aging progression in epidermal tissue.

Nicholas Holzscheck, Jörn Söhle, Boris Kristof, Elke Grönniger, Stefan Gallinat, Horst Wenck, Marc Winnefeld, Cassandra Falckenhayn, Lars Kaderali

Open access · greenAbstract read
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 34 citations in OpenAlex.

  1. Trial
  2. Embracing non-linearity in human ageing.Nature reviews. Genetics · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Age-Related Transcriptomic Changes in the Vermiform Appendix.International journal of molecular sciences · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. The landscape of aging.Science China. Life sciences · 2022
    Review
  18. Measuring biological age using omics data.Nature reviews. Genetics · 2022
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Nicholas HolzscheckFront End Innovation, Beiersdorf AG, Hamburg, Germany.
Jörn SöhleFront End Innovation, Beiersdorf AG, Hamburg, Germany.
Boris KristofFront End Innovation, Beiersdorf AG, Hamburg, Germany.
Elke GrönnigerFront End Innovation, Beiersdorf AG, Hamburg, Germany.
Stefan GallinatFront End Innovation, Beiersdorf AG, Hamburg, Germany.
Horst WenckFront End Innovation, Beiersdorf AG, Hamburg, Germany.
Marc WinnefeldFront End Innovation, Beiersdorf AG, Hamburg, Germany.
Cassandra FalckenhaynFront End Innovation, Beiersdorf AG, Hamburg, Germany.
Lars KaderaliInstitute for Bioinformatics, University Medicine Greifswald, Greifswald, Germany.
Beiersdorf (Germany) · DEUniversitätsmedizin Greifswald · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, reports of non-linear regulations in age- and longevity-associated biological processes have been accumulating. Inspired by methodological advances in precision medicine involving the integrative analysis of multi-omics data, we sought to investigate the potential of multi-omics integration to identify distinct stages in the aging progression from

Indexed as

Models, GeneticAdultAgedCluster AnalysisDNA MethylationEpidermisEpigenomicsFemaleGene Expression ProfilingHumansLogistic ModelsMachine LearningMiddle AgedSkin AgingTranscriptomeYoung Adultaging phasesbiological agehallmarks of agingmulti-omicstranscriptional noise

Identifiers

PMID32554863
PMCPMC7343460
OpenAlexW3036524281

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.