ArticleAging2020
Prenatal famine exposure and estimated glomerular filtration rate across consecutive generations: association and epigenetic mediation in a population-based cohort study in Suihua China.
Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Association between early exposure to famine and risk of renal impairment in adulthood: a systematic review and meta-analysis.Nutrition & diabetes · 2024Pooled it
- The association between prenatal famine, DNA methylation and mental disorders: a systematic review and meta-analysis.Clinical epigenetics · 2023Pooled it
- Transgenerational and intergenerational effects of early childhood famine exposure in the cohort of offspring of Leningrad Siege survivors.Scientific reports · 2023Pooled it
- Epigenetic regulation of nephrogenesis: from Waddington's landscape to adult disease.American journal of physiology. Renal physiology · 2026Review
- Association between famine exposure during early life and the risk of hyperuricemia in adulthood: a systematic review and meta-analysis.BMC nutrition · 2025Article
- Article
- Severe maternal undernutrition during pregnancy and its long-term effects on the offspring health, with a focus on kidney health.Pediatric nephrology (Berlin, Germany) · 2025Review
- Epigenome-wide association study of Chinese monozygotic twins identifies DNA methylation loci associated with estimated glomerular filtration rate.Journal of translational medicine · 2025Article
- Morphometric analysis of the intergenerational effects of protein restriction on nephron endowment in mice.Heliyon · 2024Article
- Social Determinants of Health, Diet, and Health Outcome.Nutrients · 2024Article
- Early metabolic and hemodynamic indicators of kidney dysfunction in mice offspring from parental low protein diet.Molecular and cellular pediatrics · 2024Article
- Nutrition and Developmental Origins of Kidney Disease.Nutrients · 2023Review
- The hunger strikes back: an epigenetic memory for autophagy.Cell death and differentiation · 2023Review
- Correlation of Great Chinese Famine Exposure During Early Life to Prevalence of Kidney Stone in Adulthood.International journal of general medicine · 2023Article
- Health inequities and the inappropriate use of race in nephrology.Nature reviews. Nephrology · 2022Review
- Childhood adversity correlates with stable changes in DNA methylation trajectories in children and converges with epigenetic signatures of prenatal stress.Neurobiology of stress · 2021Article
- Chinese famine and metabolic syndrome: a longitudinal cohort study in Suihua China.European journal of clinical nutrition · 2021Article
- Reply to 'Chinese famine and metabolic syndrome: a longitudinal cohort study in Suihua China'.European journal of clinical nutrition · 2021Article
- Consequences of exposure to prenatal famine on estimated glomerular filtration rate and risk of chronic kidney disease among survivors of the great Ethiopian famine (1983-85): a historical cohort study.Nutrition journal · 2021Article
- Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prenatal malnutrition could promote renal dysfunction in adulthood, but it is unclear whether the detrimental effect could be transmitted to the next generation. We investigated whether famine exposure was associated with variation of estimated glomerular filtration rate(eGFR) in two generations and explored the mediation role of methylation alterations. The longitudinal analysis included 2909 participants from Suihua rural area. F1 and F2 generations were divided into non-famine and famine group based on their birth year and exposure status of their parents, respectively. The eGFR was calculated by using the chronic kidney disease epidemiology collaboration equation. We applied mixed-effect models to investigate the association between famine and ΔeGFR and tested blood DNA methylomes in 46 families across two generations. The mediation-analysis models were utilized to examine the mediation effect of methylation alterations on the famine-ΔeGFR association.In mixed-effect models, famine exposure was associated with declined ΔeGFR level in F1(β:-8.32;95%CI:-11.51,-5.12) and in F2(β:-6.11;95%CI:-11.88, -0.43). Methylation850K BeadChip data showed only 19 of 961 F1 differentially methylated sites showed concordant alterations in F2. The mediation-analysis results showed methylation alterations on AGTR1 and PRKCA might mediate the famine-ΔeGFR association. Overall, prenatal famine exposure may have long-term effects on eGFR decline across consecutive generations which might be partly mediated by methylation alterations on AGTR1 and PRKCA.
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