ArticleEndocrinology, diabetes & metabolism case reports2020
Insulin autoimmune syndrome.
Article in Endocrinology, diabetes & metabolism case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Averting Potential Misinterpretations and Diagnostic Misapplications of Misleading Laboratory Results.Diagnostics (Basel, Switzerland) · 2026Review
- Ovarian stimulation toward oocyte cryopreservation for fertility preservation in a patient with Hirata syndrome: a clinical challenge in assisted reproduction.Archives of gynecology and obstetrics · 2026Article
- Drug-induced insulin autoimmune syndrome: a clinico-epidemiological analysis integrating pharmacovigilance data and case series.Diabetology & metabolic syndrome · 2025Article
- Hirata Syndrome in a Woman With Graves' Disease Without Exposure to Thionamides and Summary of Cases from South America.JCEM case reports · 2025Article
- Insulin Autoimmune Syndrome: A Chinese Expert Consensus Statement.Aging medicine (Milton (N.S.W)) · 2025Article
- Clinical and molecular evaluation of insulin autoimmune syndrome in a woman with Graves' disease who subsequently became pregnant: A case report.Case reports in women's health · 2024Article
- Insulin Autoimmune Syndrome (Hirata's Disease) Caused by Methimazole in a 47-Year-Old Man.Cureus · 2024Article
- Recurrent hypoglycemia induced by clopidogrel: A case report and mini review.Journal of diabetes investigation · 2024Review
- Insulin autoimmunity associated with vitiligo: a rare case presentation.Endocrinology, diabetes & metabolism case reports · 2024Article
- Insulin autoimmune syndrome without hypoglycemia: A different perspective of method interference.Northern clinics of Istanbul · 2024Article
- Complete laboratory diagnosis of Insulin Autoimmune Syndrome.Practical laboratory medicine · 2023Article
- Long-term follow-up of methimazole-associated insulin autoimmune syndrome: a rare case report.The Journal of international medical research · 2023Article
- Insulin Autoimmune Syndrome: A Systematic Review.International journal of endocrinology · 2023Review
- Scientific opinion on the relationship between intake of alpha-lipoic acid (thioctic acid) and the risk of insulin autoimmune syndrome.EFSA journal. European Food Safety Authority · 2021Article
- Safety Evaluation of α-Lipoic Acid Supplementation: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Studies.Antioxidants (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
summaryInsulin autoimmune syndrome (Hirata's disease) is a disorder caused by development of autoantibodies to insulin and manifested by hypoglycaemic syndrome. The overwhelming majority of physicians do not include it in the differential diagnosis of hypoglycaemic states because of a misconception of an extremely low prevalence of this condition. This results in unnecessary drug therapy and unjustified surgical interventions in patients that otherwise would be successfully treated conservatively. This disease is strongly associated with certain alleles of the HLA gene. In most cases, this condition develops in predisposed individuals taking drugs containing sulfhydryl groups. Formation of autoantibodies to insulin may be observed in patients with other autoimmune disorders, as well as in those with multiple myeloma or monoclonal gammopathy of undetermined significance. This paper presents the first Russian case report of insulin autoimmune syndrome in an adult patient. LEARNING POINTS: Insulin autoimmune syndrome, Hirata's disease, anti-insulin antibodies, and hypoglycaemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.