ArticlePediatrics2020
Survival Without Major Morbidity Among Very Low Birth Weight Infants in California.
Article in Pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of survival without major morbidity and associated risk factors among very preterm infants: a systematic review and meta-analysis.Frontiers in pediatrics · 2025Pooled it
- Cord blood transfusions in extremely low gestational age neonates to reduce severe retinopathy of prematurity: results of a prespecified interim analysis of the randomized BORN trial.Italian journal of pediatrics · 2024Trial
- Transcatheter-Based Palliation of Congenital Heart Disease in Very Low Birth Weight Infants.JACC. Case reports · 2026Article
- Perinatal prediction of mortality for neonates born at 22-25 weeks gestation.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Five-Minute Apgar Scores and Its Prognostic Value for Mortality and Severe Morbidity in Very Preterm Infants: A Multinational Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2026Observational
- Survival without major morbidity in extremely preterm infants: a prospective multicenter study in Shenzhen, China.Frontiers in pediatrics · 2026Article
- Article
- Bronchopulmonary Dysplasia in Asian American, Native Hawaiian, and Pacific Islander Infants with Very Low Birth Weight in California.The Journal of pediatrics · 2025Article
- Article
- Characterization of gut microbiota in very low birth weight infants with versus without bronchopulmonary dysplasia.Clinical and experimental pediatrics · 2025Article
- Trends in short-term outcomes of very low birth weight infants from a single center in Shanghai from 2013 to 2023.Translational pediatrics · 2025Article
- Retrospective study of preterm infants exposed to inhaled nitric oxide in Kaiser Permanente Southern California: morbidity, mortality and follow-up.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Comparative analysis of necrotizing enterocolitis in preterm infants born in Japan and born to mothers of Japanese ethnicity in California.Scientific reports · 2025Article
- [Impact of different treatment attitudes on survival and risk factors for poor clinical outcomes in extremely preterm infants: a retrospective real-world study].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- The Molecular Biology of Placental Transport of Calcium to the Human Foetus.International journal of molecular sciences · 2025Review
- Disparities in Survival Without Major Morbidity Among Very Low Birth Weight Infants in California.Pediatrics · 2024Article
- Article
- Temporal Dynamics of Oxidative Stress and Inflammation in Bronchopulmonary Dysplasia.International journal of molecular sciences · 2024Review
- Computational Approaches for Predicting Preterm Birth and Newborn Outcomes.Clinics in perinatology · 2024Review
- Quality, outcome, and cost of care provided to very low birth weight infants in California.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
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5 authors.
Funding
Abstract
objectivesTo examine trends in survival without major morbidity and its individual components among very low birth weight infants across California and assess remaining gaps that may be opportune targets for improvement efforts.
methodsThe study population included infants born between 2008 and 2017 with birth weights of 401 to 1500 g or a gestational age of 22 to 29 weeks. Risk-adjusted trends of survival without major morbidity and its individual components were analyzed. Survival without major morbidity was defined as the absence of death during birth hospitalization, chronic lung disease, severe peri-intraventricular hemorrhage, nosocomial infection, necrotizing enterocolitis, severe retinopathy of prematurity or related surgery, and cystic periventricular leukomalacia. Variations in adjusted rates and/or interquartile ranges were examined. To assess opportunities for additional improvement, all hospitals were reassigned to perform as if in the top quartile, and recalculation of predicted numbers were used to estimate potential benefit.
resultsIn this cohort of 49 333 infants across 142 hospitals, survival without major morbidity consistently increased from 62.2% to 66.9% from 2008 to 2017. Network variation decreased, with interquartile ranges decreasing from 21.1% to 19.2%. The largest improvements were seen for necrotizing enterocolitis and nosocomial infection. Bronchopulmonary dysplasia rates did not change significantly. Over the final 3 years, if all hospitals performed as well as the top quartile, an additional 621 infants per year would have survived without major morbidity, accounting for an additional 6.6% annual improvement.
conclusionsAlthough trends are promising, bronchopulmonary dysplasia remains a common and persistent major morbidity, remaining a target for continued quality-improvement efforts.
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