ArticleScience translational medicine2020
Restoring glucose uptake rescues neutrophil dysfunction and protects against systemic fungal infection in mouse models of kidney disease.
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Glycogen phosphorylase L confers metabolic flexibility in neutrophils to fight fungal infections in nutrient-deprived tissues.Cell host & microbe · 2026Article
- Fungal infection drives metabolic reprogramming in epithelial cells via aerobic glycolysis and an alternative TCA cycle shunt.Science advances · 2026Article
- Deletion of Galectin-3 Renders Mice Less Susceptible to Candida auris Skin Infection by Enhancing Antifungal Activity of Neutrophils.The Journal of infectious diseases · 2025Article
- Suyin Detoxification Prescription Regulates the Klotho and ERK/NF-κB Signaling Pathways to Alleviate Renal Injury.Cell biochemistry and biophysics · 2025Article
- Neutrophils and NETs in kidney disease.Nature reviews. Nephrology · 2025Review
- The survival of B cells is compromised in kidney disease.Nature communications · 2024Article
- Metabolic homeostasis in fungal infections from the perspective of pathogens, immune cells, and whole-body systems.Microbiology and molecular biology reviews : MMBR · 2024Review
- Not just sugar: metabolic control of neutrophil development and effector functions.Journal of leukocyte biology · 2024Review
- The RNA binding protein Arid5a drives IL-17-dependent autoantibody-induced glomerulonephritis.The Journal of experimental medicine · 2024Article
- Role of cell rearrangement and related signaling pathways in the dynamic process of tip cell selection.Cell communication and signaling : CCS · 2024Review
- Immune responses to human fungal pathogens and therapeutic prospects.Nature reviews. Immunology · 2023Review
- Article
- Amoeba-inspired magnetic microgel assembly assisted by engineered dextran-binding protein for vaccination against life-threatening systemic infection.Nano research · 2023Article
- Pathogenesis and virulence ofVirulence · 2022Review
- IL-23 signaling prevents ferroptosis-driven renal immunopathology during candidiasis.Nature communications · 2022Article
- Targeting immunometabolism in host-directed therapies to fungal disease.Clinical and experimental immunology · 2022Review
- Fungal sensing enhances neutrophil metabolic fitness by regulating antifungal Glut1 activity.Cell host & microbe · 2022Article
- Pathogen infection-responsive nanoplatform targeting macrophage endoplasmic reticulum for treating life-threatening systemic infection.Nano research · 2022Article
- Metabolic Regulation of Inflammation and Its Resolution: Current Status, Clinical Needs, Challenges, and Opportunities.Journal of immunology (Baltimore, Md. : 1950) · 2021Review
- Local antifungal immunity in the kidney in disseminated candidiasis.Current opinion in microbiology · 2021Review
Corrections and comments
- Commented on by
Authors and funding
15 authors at 2 institutions in 1 country.
Chetan V JawaleDivision of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0003-4621-6686
Kritika RamaniDivision of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
De-Dong LiDivision of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0002-9474-390X
Bianca M ColemanDivision of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0003-4276-7456
Rohan S OberoiDivision of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0002-8908-8760
Saran KupulDivision of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0003-3385-4558
Li LinDivision of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Jigar V DesaiFungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20814, USA.ORCID 0000-0002-8823-0796
Greg M DelgoffeDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Michail S LionakisFungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20814, USA.
Filitsa H BenderDivision of Renal-Electrolyte, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Alexander J ProkopienkoDepartment of Pharmacy and Therapeutics, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0002-8828-8365
Thomas D NolinDivision of Renal-Electrolyte, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0003-4339-1382
Sarah L GaffenDivision of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0001-8511-2041
Partha S BiswasDivision of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA. psb13@pitt.edu.ORCID 0000-0002-4570-7443
University of Pittsburgh · USNational Institute of Allergy and Infectious Diseases · US
Funding
VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0MImmunopathogenesis of Fungal InfectionsZIAAI001175 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LIONAKIS, MICHAIL · 2012 to 2025
$23.9MHost and Fungal Regulation of Type 17 Immunity to Oral CandidiasisR37DE022550 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sarah L Gaffen · 2017 to 2026
$5.6MMechanisms of neutrophil dysfunction in antifungal immunityR01AI142354 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BISWAS, PARTHA SARATHI, NOLIN, THOMAS DOUGLAS · 2019 to 2023
$2.4MDrug Metabolizing Enzyme and Transporter Function in Chronic Kidney DiseaseR01GM107122 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI JOY, MELANIE S, NOLIN, THOMAS DOUGLAS · 2014 to 2018
$2.3MIL-17 Receptor Signaling in the Oral MucosaR01DE022550 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GAFFEN, SARAH L · 2012 to 2016
$2.1MNegative Control of IL-17R Signaling: Implications for Fungal ImmunityR01AI107825 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GAFFEN, SARAH L · 2014 to 2018
$1.9MMechanisms of IL-17 Mediated Host Defense in the KidneyR01DK104680 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BISWAS, PARTHA SARATHI · 2015 to 2019
$1.5MRegulation of IL-17 signaling by RNA binding proteins in kidney diseasesR21AI145242 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BISWAS, PARTHA SARATHI, GAFFEN, SARAH L · 2019 to 2020
$424kNCI NIH HHS P30 CA047904NIAID NIH HHS R01 AI107825NIAID NIH HHS R01 AI142354NIAID NIH HHS R21 AI145242NIDCR NIH HHS R01 DE022550NIDCR NIH HHS R37 DE022550NIDDK NIH HHS R01 DK104680NIGMS NIH HHS R01 GM107122
Abstract
Disseminated candidiasis caused by the fungus
Indexed as
CandidiasisKidney DiseasesAnimalsCandida albicansGlucoseHumansMiceNeutrophilsGlucose
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.