ArticleGenetics2020
Life History Effects on Neutral Diversity Levels of Autosomes and Sex Chromosomes.
Article in Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- The Breeding Sex Ratio Interacts With Demographic History to Shape Comparative Patterns of Variation on the X Chromosome and the Autosomes.Genome biology and evolution · 2025Article
- Comparative Patterns of Variation on the X Chromosome and Autosomes: The Role of the Breeding Sex Ratio.bioRxiv : the preprint server for biology · 2025Article
- Accurate inference of population history in the presence of background selection.bioRxiv : the preprint server for biology · 2024Article
- Article
- Different historical generation intervals in human populations inferred from Neanderthal fragment lengths and mutation signatures.Nature communications · 2021Article
- Sex determination through X-Y heterogamety in Salix nigra.Heredity · 2021Article
- Changes in life history and population size can explain the relative neutral diversity levels on X and autosomes in extant human populations.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the determinants of neutral diversity patterns on autosomes and sex chromosomes provides a bedrock for the interpretation of population genetic data; in particular, differences between the two informs our understanding of sex-specific demographic and mutation processes. While sex-specific age-structure and variation in reproductive success have long been known to affect neutral diversity, theoretical descriptions of these effects were complicated and lacking in generality, stymying attempts to relate diversity patterns of species with their life history. Here, we derive general yet simple expressions for these effects. In particular, we show that life history effects on X-to-autosome ratios of pairwise diversity levels (X:A diversity ratios) depend only on the male-to-female ratios of mutation rates, generation times, and reproductive variances. Our results reveal that changing the male-to-female ratio of generation times has opposite effects on X:A ratios of diversity and divergence. They also explain how sex-specific life histories modulate the response of X:A diversity ratios to changes in population size. More generally, they clarify that sex-specific life history-generation times in particular-should have marked effects on X:A diversity ratios in many taxa and enable further investigation of these effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.