Evidence map›Paper›PMID 32554619›Full record

ArticleJournal for immunotherapy of cancer2020

Immune-related (IR)-pneumonitis during the COVID-19 pandemic: multidisciplinary recommendations for diagnosis and management.

Jarushka Naidoo, Joshua E Reuss, Karthik Suresh, David Feller-Kopman, Patrick M Forde, Seema Mehta Steinke, Clare Rock, Douglas B Johnson, Mizuki Nishino, Julie R Brahmer

Open access · goldAbstract read
In one paragraph

Article in Journal for immunotherapy of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Guideline
  2. Optimizing inpatient care for lung cancer patients with immune checkpoint inhibitor-related pneumonitis using a clinical care pathway algorithm.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. An Overview of Thermal Infrared Imaging-Based Screenings during Pandemic Emergencies.International journal of environmental research and public health · 2021
    Review
  10. Review
  11. Review
  12. Article
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Jarushka NaidooOncology, Johns Hopkins Medicine Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA jnaidoo1@jhmi.edu.ORCID 0000-0002-3470-8686
Joshua E ReussOncology, Johns Hopkins Medicine Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA.
Karthik SureshDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
David Feller-KopmanDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Patrick M FordeOncology, Johns Hopkins Medicine Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA.
Seema Mehta SteinkeDivision of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland, USA.
Clare RockDivision of Hospital Epidemiology and Infection Control, Johns Hopkins University, Baltimore, Maryland, USA.
Douglas B JohnsonOncology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Mizuki NishinoRadiology, Dana Farber Cancer Institute, Boston, Massachusetts, USA.
Julie R BrahmerOncology, Johns Hopkins Medicine Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA.
Bloomberg (United States) · USJohns Hopkins University · USDana-Farber Cancer Institute · USVanderbilt University Medical Center · US

Funding

Automated in vivo analysis of tumor growth rate as a guide for therapeutic decisions to advance personalized cancer treatmentR01CA203636 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI NISHINO, MIZUKI · 2017 to 2021
$2.9M
Metabolic regulation of Ca2+ entry and endothelial-mesenchymal transition in pulmonary arterial hypertensionR01HL151530 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SURESH, KARTHIK · 2021 to 2025
$2.0M
ROS-induced endothelial dysfunction in pulmonary arterial hypertensionK08HL132055 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SURESH, KARTHIK · 2017 to 2021
$828k
NCI NIH HHS R01 CA203636NHLBI NIH HHS K08 HL132055NHLBI NIH HHS R01 HL151530
6 · The paper itself

Abstract

Immune-related (IR)-pneumonitis is a rare and potentially fatal toxicity of anti-PD(L)1 immunotherapy. Expert guidelines for the diagnosis and management of IR-pneumonitis include multidisciplinary input from medical oncology, pulmonary medicine, infectious disease, and radiology specialists. Severe acute respiratory syndrome coronavirus 2 is a recently recognized respiratory virus that is responsible for causing the COVID-19 global pandemic. Symptoms and imaging findings from IR-pneumonitis and COVID-19 pneumonia can be similar, and early COVID-19 viral testing may yield false negative results, complicating the diagnosis and management of both entities. Herein, we present a set of multidisciplinary consensus recommendations for the diagnosis and management of IR-pneumonitis in the setting of COVID-19 including: (1) isolation procedures, (2) recommended imaging and interpretation, (3) adaptations to invasive testing, (4) adaptations to the management of IR-pneumonitis, (5) immunosuppression for steroid-refractory IR-pneumonitis, and (6) management of suspected concurrent IR-pneumonitis and COVID-19 infection. There is an emerging need for the adaptation of expert guidelines for IR-pneumonitis in the setting of the global COVID-19 pandemic. We propose a multidisciplinary consensus on this topic, in this position paper.

Indexed as

Practice Guidelines as TopicAntineoplastic Agents, ImmunologicalB7-H1 AntigenBetacoronavirusConsensusCoronavirus InfectionsCOVID-19HumansInfectious Disease MedicineInterdisciplinary CommunicationLungMedical OncologyNeoplasmsPandemicsPneumoniaPneumonia, ViralAntineoplastic Agents, ImmunologicalB7-H1 AntigenCD274 protein, humanautoimmunityguidelines as topicimmunotherapy

Identifiers

PMID32554619
PMCPMC7316105
OpenAlexW3036659746

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.