Evidence map›Paper›PMID 32554617›Full record

ReviewJournal for immunotherapy of cancer2020

Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer.

Ananth Annapragada, Andrew Sikora, Catherine Bollard, Jose Conejo-Garcia, Conrad Russell Cruz, Shadmehr Demehri, Michael Demetriou, Levon Demirdjian, Lawrence Fong, Mary Horowitz and 17 more

Abstract readReview
In one paragraph

Review in Journal for immunotherapy of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  2. Article
  3. Review
  4. Just how transformative will AI/ML be for immuno-oncology?Journal for immunotherapy of cancer · 2024
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Ananth AnnapragadaSingleton Department of Pediatric Radiology, Texas Children's Hospital, Houston, Texas, USA.
Andrew SikoraBobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, USA.
Catherine BollardCenter for Cancer and Immunology Research, Children's National Medical Center, Washington, District of Columbia, USA.
Jose Conejo-GarciaDepartment of Immunology, H Lee Moffitt Cancer Center and Research Center, Tampa, Florida, USA.
Conrad Russell CruzCenter for Cancer and Immunology Research, Children's National Medical Center, Washington, District of Columbia, USA.
Shadmehr DemehriDepartment of Dermatology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Michael DemetriouDepartment of Neurology, University of California Irvine, Irvine, California, USA.
Levon DemirdjianCenter for Computational and Genomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Lawrence FongDepartment of Hematology and Oncology, University of California San Francisco, San Francisco, California, USA.
Mary HorowitzDepartment of Medicine, Medical College of Wisconsin and Center for International Blood and Marrow Transplant Research, Milwaukee, Wisconsin, USA
Alan HutsonDepartment of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, New York, USA.
Kathryn Kadash-EdmondsonCenter for Computational and Genomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Donald KufeDepartment of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA.
Steven LipkinDepartment of Medicine, Weill Cornell Medicine, New York, New York, USA.
Song LiuDepartment of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, New York, USA.
Claire McCarthyDivision of Cancer Biology, National Cancer Institute, Rockville, Maryland, USA.
Martin MorganDepartment of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, New York, USA.
Zachary MorrisDepartment of Human Oncology, University of Wisconsin Madison School of Medicine and Public Health, Madison, Wisconsin, USA.
Yang PanCenter for Computational and Genomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Marcelo PasquiniDivision of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
Stephen SchoenbergerDepartment of Clinical Cancer Prevention, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Eliezer Van AllenDepartment of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA.
Eduardo VilarDepartment of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA
Yi XingCenter for Computational and Genomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Wenjuan ZhaDepartment of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, New York, USA.
IOTN Consortium
Adekunle OdunsiDepartment of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA

Funding

Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
Immuno-Oncology Translation Network (IOTN): Cellular Immunotherapy Data Resource (CIDR)U24CA233032 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI PASQUINI, MARCELO C. · 2018 to 2019
$9.0M
Immuno-Oncology Translation Network: Data Management and Resource-Sharing Center at RPCIU24CA232979 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI HUTSON, ALAN DAVID, LIU, SONG · 2018 to 2024
$8.9M
Th1 polarizing immune responses using DNA origamiU54CA244726 · NCI · HARVARD UNIVERSITY · PI HODI, FRANK S, MOONEY, DAVID J · 2019 to 2019
$8.2M
User-control and safetyU54CA244438 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIM, WENDELL A · 2019 to 2022
$7.8M
Project 3U54CA244711 · NCI · UNIVERSITY OF PENNSYLVANIA · PI JUNE, CARL H. · 2019 to 2022
$7.1M
Vascular Leukocytes Influence the Tumor MicroenvironmentR01CA124515 · NCI · WISTAR INSTITUTE · PI Jose R Conejo-Garcia · 2007 to 2026
$7.1M
Project 3U54CA244719 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI CHEN, ZHIJIAN J · 2019 to 2019
$5.2M
Stimulating Neo-Antigen Specific T Cell Responses in Head and Neck CancersU01DE028227 · NIDCR · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI GUTKIND, JORGE SILVIO, RAO, ANJANA · 2018 to 2022
$4.6M
Defining mechanisms of immunotherapy resistance in head and neck squamous cell carcinomasU01DE029188 · NIDCR · DANA-FARBER CANCER INST · PI BARBIE, DAVID A, HADDAD, ROBERT I. · 2019 to 2019
$4.3M
Preventing Myeloma Relapse after Autologous Stem Cell Transplantation with Decoy Resistant IL-18U01CA244291 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HILL, GEOFFREY ROGER · 2019 to 2022
$4.2M
Molecular and immune drivers of immunotherapy responsiveness in prostate cancerU01CA233100 · NCI · DANA-FARBER CANCER INST · PI FONG, LAWRENCE, VAN ALLEN, ELIEZER M · 2018 to 2022
$4.2M
NCI NIH HHS R01 CA124515NCI NIH HHS R01 CA157664NCI NIH HHS U01 CA232758NCI NIH HHS U01 CA233056NCI NIH HHS U01 CA233074NCI NIH HHS U01 CA233078NCI NIH HHS U01 CA233084NCI NIH HHS U01 CA233085NCI NIH HHS U01 CA233096NCI NIH HHS U01 CA233097NCI NIH HHS U01 CA233100NCI NIH HHS U01 CA233102NCI NIH HHS U01 CA239258NCI NIH HHS U01 CA244291NCI NIH HHS U01 CA244314NCI NIH HHS U01 CA244452NCI NIH HHS U24 CA076518NCI NIH HHS U24 CA232979NCI NIH HHS U24 CA233032NCI NIH HHS U54 CA244438NCI NIH HHS U54 CA244711NCI NIH HHS U54 CA244719NCI NIH HHS U54 CA244726NCI NIH HHS UG3 CA244687NCI NIH HHS UG3 CA244697NIAAA NIH HHS U01 AA027681NIDCR NIH HHS U01 DE028227NIDCR NIH HHS U01 DE028233NIDCR NIH HHS U01 DE029188NIDCR NIH HHS U01 DE029255
6 · The paper itself

Abstract

Despite regulatory approval of several immune-based treatments for cancer in the past decade, a number of barriers remain to be addressed in order to fully harness the therapeutic potential of the immune system and provide benefits for patients with cancer. As part of the Cancer Moonshot initiative, the Immuno-Oncology Translational Network (IOTN) was established to accelerate the translation of basic discoveries to improve immunotherapy outcomes across the spectrum of adult cancers and to develop immune-based approaches that prevent cancers before they occur. The IOTN currently consists of 32 academic institutions in the USA. By leveraging cutting-edge preclinical research in immunotherapy and immunoprevention, open data and resource sharing, and fostering highly collaborative team science across the immuno-oncology ecosystem, the IOTN is designed to accelerate the generation of novel mechanism-driven immune-based cancer prevention and therapies, and the development of safe and effective personalized immuno-oncology approaches.

Indexed as

HumansImmunotherapyMedical OncologyNeoplasmsimmunityimmunotherapy

Identifiers

PMID32554617
PMCPMC7304845

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.