Evidence map›Paper›PMID 32554600›Full record

ArticleGenetics2020

Electrophysiological Alterations of Pyramidal Cells and Interneurons of the CA1 Region of the Hippocampus in a Novel Mouse Model of Dravet Syndrome.

David A Dyment, Sarah C Schock, Kristen Deloughery, Minh Hieu Tran, Kerstin Ure, Lauryl M J Nutter, Amie Creighton, Julie Yuan, Umberto Banderali, Tanya Comas and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Dravet syndrome: novel insights intoFrontiers in neuroscience · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

David A DymentChildren's Hospital of Eastern Ontario Research Institute, University of Ottawa, K1H 8L1 Ontario, Canada ddyment@cheo.on.ca.
Sarah C SchockDepartment of Genetics, Children's Hospital of Eastern Ontario, Ottawa, K1H 8L1 Ontario, Canada.
Kristen DelougheryDepartment of Genetics, Children's Hospital of Eastern Ontario, Ottawa, K1H 8L1 Ontario, Canada.
Minh Hieu TranDepartment of Genetics, Children's Hospital of Eastern Ontario, Ottawa, K1H 8L1 Ontario, Canada.
Kerstin UreBehaviour and Physiology Core, University of Ottawa, K19 6N5 Ontario, Canada.
Lauryl M J NutterThe Centre for Phenogenomics, The Hospital for Sick Children, Toronto, M5T 3H7, Ontario, Canada.
Amie CreightonThe Centre for Phenogenomics, The Hospital for Sick Children, Toronto, M5T 3H7, Ontario, Canada.
Julie YuanThe Centre for Phenogenomics, The Hospital for Sick Children, Toronto, M5T 3H7, Ontario, Canada.
Umberto BanderaliNational Research Council of Canada, Human Health Therapeutics Research Center, Ottawa, K1A 0R6 Ontario, Canada.
Tanya ComasNational Research Council of Canada, Human Health Therapeutics Research Center, Ottawa, K1A 0R6 Ontario, Canada.
Ewa BaumannNational Research Council of Canada, Human Health Therapeutics Research Center, Ottawa, K1A 0R6 Ontario, Canada.
Anna JezierskiNational Research Council of Canada, Human Health Therapeutics Research Center, Ottawa, K1A 0R6 Ontario, Canada.
Care4Rare Canada Consortium,
Kym M BoycottChildren's Hospital of Eastern Ontario Research Institute, University of Ottawa, K1H 8L1 Ontario, Canada.
Alex E MackenzieChildren's Hospital of Eastern Ontario Research Institute, University of Ottawa, K1H 8L1 Ontario, Canada.
Marzia MartinaNational Research Council of Canada, Human Health Therapeutics Research Center, Ottawa, K1A 0R6 Ontario, Canada.
National Research Council Canada · CAChildren's Hospital of Eastern Ontario · CAUniversity of Ottawa · CASickKids Foundation · CAHospital for Sick Children · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dravet syndrome is a developmental epileptic encephalopathy caused by pathogenic variation in

Indexed as

Disease Models, AnimalAnimalsCA1 Region, HippocampalElectrophysiologyEpilepsies, MyoclonicFemaleFibroblastsHumansInduced Pluripotent Stem CellsInterneuronsMaleMembrane PotentialsMiceMice, Inbred C57BLMutationNAV1.1 Voltage-Gated Sodium ChannelNAV1.1 Voltage-Gated Sodium ChannelSCN1A protein, humanScn1a protein, mouseCA1Dravet syndromehippocampusinduced neuronsinterneuronsmouse modelpyramidal cellssodium current

Identifiers

PMID32554600
PMCPMC7404236
OpenAlexW3035806510

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.