ArticleScience (New York, N.Y.)2020
Manipulating synthetic optogenetic odors reveals the coding logic of olfactory perception.
Article in Science (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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Who cites it
86 citing papers in PubMed.
- Elements of olfactory intelligence in Drosophila.Biological cybernetics · 2026Article
- A standard model for the vertebrate retina.Vision research · 2026Article
- Rapid odorant metabolism organizes identity- and timing-based odor representations by olfactory bulb inputs and outputs.bioRxiv : the preprint server for biology · 2026Article
- Evidence that interglomerular inhibition generates non-monotonic concentration-response relationships in mitral/tufted glomeruli in the mouse olfactory bulb.The Journal of physiology · 2026Article
- Adult-neurogenesis allows for representational stability and flexibility in early olfactory system.eLife · 2026Article
- Rapid temporal processing in the olfactory bulb underlies concentration-invariant odor identification and signal decorrelation.Nature neuroscience · 2026Article
- Contribution of spike timing to the neural code: from fast to slow timescales.Biological cybernetics · 2026Review
- Isotonic and minimally invasive optical clearing media for live cell imaging ex vivo and in vivo.Nature methods · 2026Article
- A topographical organization in the primary olfactory cortex.Nature communications · 2026Article
- Odor identity decoding by mitral/tufted cells in the olfactory bulb from large-scale pooled datasets.iScience · 2026Article
- Temporal sequence geometry enables odor recognition and generalization.bioRxiv : the preprint server for biology · 2026Article
- Organizational closure through regenerative signaling as a possible basis for conscious awareness.Frontiers in computational neuroscience · 2026Review
- Patterned wireless transcranial optogenetics generates artificial perception.Nature neuroscience · 2026Article
- Order code in the olfactory system.bioRxiv : the preprint server for biology · 2025Article
- Simultaneous detection and estimation in olfactory sensing.bioRxiv : the preprint server for biology · 2025Article
- Article
- Mouse olfactory system acts as anemo-detector and anemo-discriminator.Science advances · 2025Article
- Basal forebrain cholinergic input mediates adaptive attention allocation to enhance olfactory discrimination.PLoS biology · 2025Article
- Evidence that interglomerular inhibition generates non-monotonic concentration-response relationships in mitral/tufted glomeruli in the mouse olfactory bulb.bioRxiv : the preprint server for biology · 2025Article
- Decoding olfactory bulb output: A behavioral assessment of rate, synchrony, and respiratory phase coding.iScience · 2025Article
26 more citing papers are in PubMed but not listed here.
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6 authors.
Funding
Abstract
How does neural activity generate perception? Finding the combinations of spatial or temporal activity features (such as neuron identity or latency) that are consequential for perception remains challenging. We trained mice to recognize synthetic odors constructed from parametrically defined patterns of optogenetic activation, then measured perceptual changes during extensive and controlled perturbations across spatiotemporal dimensions. We modeled recognition as the matching of patterns to learned templates. The templates that best predicted recognition were sequences of spatially identified units, ordered by latencies relative to each other (with minimal effects of sniff). Within templates, individual units contributed additively, with larger contributions from earlier-activated units. Our synthetic approach reveals the fundamental logic of the olfactory code and provides a general framework for testing links between sensory activity and perception.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.