Evidence map›Paper›PMID 32554554›Full record

SynthesisRNA (New York, N.Y.)2020

Meta-analysis of transcriptomic variation in T-cell populations reveals both variable and consistent signatures of gene expression and splicing.

Caleb M Radens, Davia Blake, Paul Jewell, Yoseph Barash, Kristen W Lynch

Open access · greenAbstract readMeta-Analysis
In one paragraph

Synthesis in RNA (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Innateness transcriptome gradients characterize mouse T lymphocyte populations.Journal of immunology (Baltimore, Md. : 1950) · 2025
    Article
  5. Article
  6. Article
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  10. Review
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  12. Review
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  16. Article
  17. Chromatin Modifications in 22q11.2 Deletion Syndrome.Journal of clinical immunology · 2021
    Article
  18. Review
  19. Article
  20. Differential Regulation of Interferon Signaling Pathways in CD4International journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Caleb M RadensCell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Davia BlakeImmunology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Paul JewellDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Yoseph BarashCell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Kristen W LynchCell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
University of Pennsylvania · US

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008216 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI EPSTEIN, DOUGLAS J · 1987 to 2023
$8.3M
Signal-Induced Regulation of Alternative RNA ProcessingR35GM118048 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI KRISTEN W LYNCH · 2016 to 2026
$6.6M
Methods for RNA splicing variations detection, quantification, visualization, and association from large heterogeneous datasetsR01GM128096 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BARASH, YOSEPH · 2018 to 2021
$1.8M
CD28 Regulation of Alternative Splicing Changes in Human T cellsF31GM140978 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BLAKE, DAVIA · 2020 to 2023
$90k
NIGMS NIH HHS F31 GM140978NIGMS NIH HHS R01 GM128096NIGMS NIH HHS R35 GM118048NIGMS NIH HHS T32 GM008216
6 · The paper itself

Abstract

Human CD4

Indexed as

AdultCD4-Positive T-LymphocytesCells, CulturedCytokinesFemaleGene ExpressionHumansMaleMiddle AgedRNA SplicingT-Lymphocyte SubsetsTranscriptomeCytokinesalternative splicingT cellsTh1Th17Th2transcriptomicsTreg

Identifiers

PMID32554554
PMCPMC7491319
OpenAlexW3036258490

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.