Evidence map›Paper›PMID 32554431›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2020

IL-23 Promotes a Coordinated B Cell Germinal Center Program for Class-Switch Recombination to IgG2b in BXD2 Mice.

Huixian Hong, Min Gao, Qi Wu, PingAr Yang, Shanrun Liu, Hao Li, Peter D Burrows, Daniel Cua, Jake Y Chen, Hui-Chen Hsu and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. IL-4 alters TLR7-induced B cell developmental program in lupus.Clinical immunology (Orlando, Fla.) · 2025
    Article
  2. Review
  3. Article
  4. Article
  5. Increased development of T-betClinical immunology (Orlando, Fla.) · 2023
    Article
  6. Article
  7. Article
  8. Single cell profiling of CD45Journal of neuroinflammation · 2022
    Article
  9. Article
  10. IL-23/IL-17 Axis in Inflammatory Rheumatic Diseases.Clinical reviews in allergy & immunology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Huixian HongDivision of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL.
Min GaoInformatics Institute, the University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0002-5592-9349
Qi WuDivision of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL.
PingAr YangDivision of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL.
Shanrun LiuDivision of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0002-7201-4212
Hao LiBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.ORCID 0000-0002-2171-8826
Peter D BurrowsDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0002-5752-5647
Daniel CuaDiscovery Research, Merck Research Laboratory, Boston, MA; and.
Jake Y ChenInformatics Institute, the University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0001-8829-7504
Hui-Chen HsuDivision of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0002-0317-5725
John D MountzDivision of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL; jdmountz@uabmc.edu.
University of Alabama at Birmingham · USBeth Israel Deaconess Medical Center · USMerck & Co., Inc., Rahway, NJ, USA (United States) · US

Funding

ROS Modulation of Innate and Adaptive Immunity in RAP30AR048311 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MOUNTZ, JOHN D · 2001 to 2017
$9.5M
Suppression of pathogenic autoantibodies in lupus by inhibition of AIDR01AI071110 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MOUNTZ, JOHN D · 2008 to 2018
$4.0M
B cell intrinsic interferon-beta regulates autoreactive B cell developmentR01AI134023 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MOUNTZ, JOHN D · 2018 to 2022
$2.4M
Entry of antigen-presenting B cells into the follicle directed by IFNa and IL-17R01AI083705 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HSU, HUI-CHEN · 2011 to 2015
$1.8M
Regulation of Migration of Autoreactive Germinal Centers and Precursor B CellsI01BX000600 · VA · BIRMINGHAM VA MEDICAL CENTER · PI MOUNTZ, JOHN D · 2009 to 2017
–
Interferon Beta Initiated Development of Immunogenic T1 B cells in LupusI01BX004049 · VA · BIRMINGHAM VA MEDICAL CENTER · PI MOUNTZ, JOHN D · 2018 to 2022
–
BLRD VA I01 BX000600BLRD VA I01 BX004049NIAID NIH HHS R01 AI071110NIAID NIH HHS R01 AI083705NIAID NIH HHS R01 AI134023NIAMS NIH HHS P30 AR048311
6 · The paper itself

Abstract

IL-23 promotes autoimmune disease, including Th17 CD4 T cell development and autoantibody production. In this study, we show that a deficiency of the p19 component of IL-23 in the autoimmune BXD2 (BXD2-

Indexed as

AnimalsAutoimmune DiseasesB-LymphocytesCell DifferentiationCyclin-Dependent Kinase Inhibitor p19Germinal CenterImmunoglobulin Class SwitchingImmunoglobulin GInterferon-gammaInterleukin-23MiceMice, Inbred C57BLMice, KnockoutTh17 CellsT-Lymphocyte SubsetsCdkn2d protein, mouseCyclin-Dependent Kinase Inhibitor p19Immunoglobulin GInterferon-gammaInterleukin-23

Identifiers

PMID32554431
PMCPMC7374065
OpenAlexW3036785389

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.