ArticleEpilepsy & behavior : E&B2020
Neuroticism in temporal lobe epilepsy is associated with altered limbic-frontal lobe resting-state functional connectivity.
Article in Epilepsy & behavior : E&B, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 18 citations in OpenAlex.
- Paired associates learning performance in rats requires the nucleus reuniens.Behavioral neuroscience · 2026Article
- A pilot study of inter-regional phase amplitude coupling as comorbid depression biomarker in temporal lobe epilepsy.Epilepsy & behavior : E&B · 2025Article
- Anxiety and depression symptoms mediate the impact of neuroticism on insomnia in adults with epilepsy: a cross-sectional study.BMC neurology · 2025Article
- Functional connectivity characteristics of epilepsy with anxiety: A resting-state functional near-infrared spectroscopy study.Medicine · 2025Observational
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- Aberrant white matter and subcortical gray matter functional network connectivity associated with static and dynamic characteristics in subjects with temporal lobe epilepsy.Frontiers in neuroscience · 2025Article
- Preliminary MRS study of critical values of relevant brain metabolites in elderly Chinese patients with post-stroke cognitive impairment.IBRO neuroscience reports · 2023Article
- Association of neighborhood deprivation with white matter connectome abnormalities in temporal lobe epilepsy.Epilepsia · 2023Article
- Multimodal connectome biomarkers of cognitive and affective dysfunction in the common epilepsies.Network neuroscience (Cambridge, Mass.) · 2022Article
- Abnormal hubs in global network as neuroimaging biomarker in right temporal lobe epilepsy at rest.Frontiers in psychiatry · 2022Article
- Divergent Anatomical Correlates and Functional Network Connectivity Patterns in Temporal Lobe Epilepsy with and Without Depression.Brain topography · 2021Article
- Comparison of Emotional Regulation During Controlling Neuroticism in Different Types of Premenstrual Syndrome in Students.Iranian journal of nursing and midwifery researchArticle
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Authors and funding
23 authors at 4 institutions in 1 country.
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Abstract
Neuroticism, a core personality trait characterized by a tendency towards experiencing negative affect, has been reported to be higher in people with temporal lobe epilepsy (TLE) compared with healthy individuals. Neuroticism is a known predictor of depression and anxiety, which also occur more frequently in people with TLE. The purpose of this study was to identify abnormalities in whole-brain resting-state functional connectivity in relation to neuroticism in people with TLE and to determine the degree of unique versus shared patterns of abnormal connectivity in relation to elevated symptoms of depression and anxiety. Ninety-three individuals with TLE (55 females) and 40 healthy controls (18 females) from the Epilepsy Connectome Project (ECP) completed measures of neuroticism, depression, and anxiety, which were all significantly higher in people with TLE compared with controls. Resting-state functional connectivity was compared between controls and groups with TLE with high and low neuroticism using analysis of variance (ANOVA) and t-test. In secondary analyses, the same analytics were performed using measures of depression and anxiety and the unique variance in resting-state connectivity associated with neuroticism independent of symptoms of depression and anxiety identified. Increased neuroticism was significantly associated with hyposynchrony between the right hippocampus and Brodmann area (BA) 9 (region of prefrontal cortex (PFC)) (p < 0.005), representing a unique relationship independent of symptoms of depression and anxiety. Hyposynchrony of connection between the right hippocampus and BA47 (anterior frontal operculum) was associated with high neuroticism and with higher depression and anxiety scores (p < 0.05), making it a shared abnormal connection for the three measures. In conclusion, increased neuroticism exhibits both unique and shared patterns of abnormal functional connectivity with depression and anxiety symptoms between regions of the mesial temporal and frontal lobe.
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