Evidence map›Paper›PMID 32553836›Full record

Trial reportThe Journal of pediatrics2020

Early Weight Gain Forecasts Accelerated Eruption of Deciduous Teeth and Later Overweight Status during the First Year.

Julie A Mennella, Ashley Reiter, Benjamin Brewer, Ryan T Pohlig, Virginia A Stallings, Jillian C Trabulsi

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in The Journal of pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01667549 (Sensitive Periods in Human Flavor Learning), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01667549 nacompletednot on this map

Sensitive Periods in Human Flavor Learning

TypeinterventionalSponsorMonell Chemical Senses CenterRan2012 to 2015Enrolled97ConditionsDevelopmentArmsTiming of Diet and Flavor Experience
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Primary tooth emergence in young children is associated with a stress biomarker.Journal of developmental origins of health and disease · 2026
    Article
  4. Observational
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Julie A MennellaMonell Chemical Senses Center, Philadelphia, PA. Electronic address: mennella@monell.org.
Ashley ReiterMonell Chemical Senses Center, Philadelphia, PA.
Benjamin BrewerUniversity of Delaware, Newark, DE.
Ryan T PohligUniversity of Delaware, Newark, DE.
Virginia A StallingsChildren's Hospital of Philadelphia, Division of Gastroenterology, Hepatology and Nutrition, Philadelphia, PA.
Jillian C TrabulsiUniversity of Delaware, Newark, DE.
University of Delaware · USMonell Chemical Senses Center · USChildren's Hospital of Philadelphia · US

Funding

Taste of medicines for children: genetic variation and medical adherenceR01DC011287 · NIDCD · MONELL CHEMICAL SENSES CENTER · PI LOWENTHAL, ELIZABETH DAWN, MENNELLA, JULIA ANNE · 2011 to 2022
$4.3M
MODEL FOR SENSITIVE PERIODS IN EARLY FLAVOR LEARNINGR01HD037119 · NICHD · MONELL CHEMICAL SENSES CENTER · PI MENNELLA, JULIA ANNE · 1999 to 2016
$3.9M
Impact of diet composition during infancy on energy balance, satiety and growthR01HD072307 · NICHD · MONELL CHEMICAL SENSES CENTER · PI MENNELLA, JULIA ANNE, TRABULSI, JILLIAN CHRISTINE · 2012 to 2016
$2.7M
SECONDARY ANALYSES OF RCT DATA ON SENSITIVE PERIODS IN FLAVOR LEARNING AND DIET AMONG BREASTFEEDING DYADSR03HD102303 · NICHD · MONELL CHEMICAL SENSES CENTER · PI MENNELLA, JULIA ANNE, TRABULSI, JILLIAN CHRISTINE · 2020 to 2021
$196k
Secondary Analyses of RCT Data on Infant Formula and Nutritional ProgrammingR03HD094908 · NICHD · MONELL CHEMICAL SENSES CENTER · PI MENNELLA, JULIA ANNE, TRABULSI, JILLIAN CHRISTINE · 2018 to 2019
$173k
NICHD NIH HHS R01 HD037119NICHD NIH HHS R01 HD072307NICHD NIH HHS R03 HD094908NICHD NIH HHS R03 HD102303NIDCD NIH HHS R01 DC011287
6 · The paper itself

Abstract

objectivesTo determine whether early diet and weight gain velocity have independent or interactive effects on deciduous teeth emergence and overweight status during the first year. STUDY

designMonthly measures of anthropometry and teeth eruption were collected during a 1-year trial (0.5-12.5 months) on formula-fed infants in which the type of randomized infant formula (cow milk or extensively hydrolyzed protein) diet significantly affected early (0.5-4.5 months) weight gain velocity. Generalized linear mixed models determined whether early diet and weight gain velocity had independent or interactive effects on timing and pattern of teeth eruption. Data from a trial on breastfed infants were used to explore effects of breast milk vs infant formula diets on teeth eruption and overweight status at 10.5 months.

resultsIndependent of infant formula diet, velocities of weight gain had direct effects on the age of first deciduous tooth (P < .04) and number of erupted teeth over time (P < .002). Greater velocity of weight gain from 0.5 to 4.5 months caused earlier and more frequent eruption of deciduous teeth from 4.5 to 12.5 months. Exploratory follow-up analyses on the breastfed and formula-fed diet groups found early weight gain velocity (P = .001), but not diet or its interaction, had significant effects. Infants in the upper quartile for weight gain velocity had more primary teeth (P = .002), and a greater proportion of them were overweight (P < .001) at 10.5 months.

conclusionsFaster weight gain accretion forecasted accelerated primary teeth eruption and increased percentage of children who were overweight-risk factors for dental caries and obesity.

trial registrationClinicalTrials.govNCT01700205 [2012-2015] and NCT01667549 [2012-2015].

Indexed as

Child DevelopmentFemaleHumansInfantInfant FormulaInfant Nutritional Physiological PhenomenaMalePediatric ObesityTooth EruptionWeight Gainbreast milkdeciduous teethdevelopmental milestonesdietinfant formulaoverweight statusweight gain velocity

Identifiers

PMID32553836
PMCPMC7529945
OpenAlexW3034328339

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.