Evidence map›Paper›PMID 32553785›Full record

ArticleJournal of the American Academy of Child and Adolescent Psychiatry2021

Mind-Wandering in Adolescents Predicts Worse Affect and Is Linked to Aberrant Default Mode Network-Salience Network Connectivity.

Christian A Webb, Elana S Israel, Emily Belleau, Lindsay Appleman, Erika E Forbes, Diego A Pizzagalli

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

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  11. Low mood, worry and mind wandering in children.The British journal of developmental psychology · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Christian A WebbMcLean Hospital, Belmont, Massachusetts, and Harvard Medical School, Boston, Massachusetts. Electronic address: cwebb@mclean.harvard.edu.
Elana S IsraelMcLean Hospital, Belmont, Massachusetts, and Harvard Medical School, Boston, Massachusetts.
Emily BelleauMcLean Hospital, Belmont, Massachusetts, and Harvard Medical School, Boston, Massachusetts.
Lindsay ApplemanMcLean Hospital, Belmont, Massachusetts, and Harvard Medical School, Boston, Massachusetts.
Erika E ForbesUniversity of Pittsburgh, Pennsylvania.
Diego A PizzagalliMcLean Hospital, Belmont, Massachusetts, and Harvard Medical School, Boston, Massachusetts.
Harvard University · USUniversity of Pittsburgh · US

Funding

Neuroimaging Studies of Reward Processing in DepressionR37MH068376 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI Diego A Pizzagalli · 2016 to 2026
$7.4M
Predicting the onset of depression in at-risk adolescents from endophenotype profilesR01MH116969 · NIMH · MCLEAN HOSPITAL · PI WEBB, CHRISTIAN ANTHONY · 2019 to 2024
$2.8M
Neural Correlates of Stress and Perceived Control in Adolescent DepressionK23MH122668 · NIMH · MCLEAN HOSPITAL · PI BELLEAU, EMILY · 2020 to 2024
$960k
Examining Reward-Related Predictors and Mechanisms of Change in BA Treatment for Anhedonic AdolescentsK23MH108752 · NIMH · MCLEAN HOSPITAL · PI WEBB, CHRISTIAN ANTHONY · 2015 to 2018
$703k
NIMH NIH HHS K23 MH108752NIMH NIH HHS K23 MH122668NIMH NIH HHS R01 MH116969NIMH NIH HHS R37 MH068376
6 · The paper itself

Abstract

objectiveUnderstanding the fluctuating emotional and cognitive states of adolescents with depressive symptoms requires fine-grained and naturalistic measurements. This study used ecological momentary assessment (EMA) to investigate the affective correlates and consequences of mind-wandering in adolescents with anhedonia (AH) and typically developing (TD) controls. In addition, we examined the association between mind-wandering and resting state functional connectivity between the medial prefrontal cortex (mPFC), a core hub of the default mode network (DMN) linked to internally oriented mentation, and networks linked to attentional control (dorsal attention network [DAN]) and affect/salience detection (salience network [SN]).

methodA total of 65 adolescents, aged 12 to 18 years (TD = 36; AH = 29), completed a resting state functional magnetic resonance imaging scan and subsequently used a smartphone application for ecological momentary assessment (EMA) data collection (2-3 times/d for 5 days). Each survey (N = 678) prompted adolescents to report on their current positive and negative affect (PA and NA), cognition, and activity.

resultsThe frequency of mind-wandering was higher for AH (70.0% of EMA samples) relative to TD (59.2%) participants, and the participants with AH were more likely to mind-wander to unpleasant content. Mind-wandering was associated with higher concurrent NA, even when controlling for plausible confounds (eg, current activity, social companion, rumination). Time-lagged analyses revealed a bidirectional association between mind-wandering and PA. Greater levels of mind-wandering within the AH group were associated with stronger mPFC-SN/DAN connectivity.

conclusionRates of mind-wandering were high, especially among adolescents with anhedonia, and predicted worse affect. The relation between mind-wandering and enhanced mPFC-SN coupling may reflect heightened bottom-up influence of affective and sensory salience on DMN-mediated internally oriented thought.

Indexed as

Default Mode NetworkNerve NetAdolescentBrainBrain MappingChildCognitionHumansMagnetic Resonance ImagingPrefrontal Cortexadolescentsanhedoniaecological momentary assessmentfunctional connectivitymind-wandering

Identifiers

PMID32553785
PMCPMC7736484
OpenAlexW3035018223

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.