ArticleMetabolism: clinical and experimental2020
A multi-omic analysis of birthweight in newborn cord blood reveals new underlying mechanisms related to cholesterol metabolism.
Article in Metabolism: clinical and experimental, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Metabolomic signatures associated with fetal growth restriction and small for gestational age: a systematic review.Nature communications · 2024Pooled it
- Cord blood epigenome-wide meta-analysis in six European-based child cohorts identifies signatures linked to rapid weight growth.BMC medicine · 2023Pooled it
- Blood and adipose tissue DNA methylation in adults born preterm with a very low birth weight - a sibling comparison study.Epigenomics · 2026Article
- Breaking rules: the complex relationship between DNA methylation and X-chromosome inactivation in the human placenta.Biology of sex differences · 2025Article
- Progress in toxicogenomics to protect human health.Nature reviews. Genetics · 2025Review
- Article
- Epigenetic Responses to Nonchemical Stressors: Potential Molecular Links to Perinatal Health Outcomes.Current environmental health reports · 2024Review
- Methylation of serotonin regulating genes in cord blood cells: association with maternal metabolic parameters and correlation with methylation in peripheral blood cells during childhood and adolescence.Clinical epigenetics · 2024Article
- Article
- Prenatal Exposure to Metabolism-Disrupting Chemicals, Cord Blood Transcriptome Perturbations, and Birth Weight in a Belgian Birth Cohort.International journal of molecular sciences · 2023Article
- Epigenome-wide analysis of maternal exposure to green space during gestation and cord blood DNA methylation in the ENVIRONAGE cohort.Environmental research · 2023Article
- IDSL.UFA Assigns High-Confidence Molecular Formula Annotations for Untargeted LC/HRMS Data Sets in Metabolomics and Exposomics.Analytical chemistry · 2022Article
- Cord blood metabolites and rapid postnatal growth as multiple mediators in the prenatal propensity to childhood overweight.International journal of obesity (2005) · 2022Article
- IDSL.IPA Characterizes the Organic Chemical Space in Untargeted LC/HRMS Data Sets.Journal of proteome research · 2022Article
- Strengthening Causal Inference in Exposomics Research: Application of Genetic Data and Methods.Environmental health perspectives · 2022Article
- Associations of maternal and infant metabolite profiles with foetal growth and the odds of adverse birth outcomes.Pediatric obesity · 2022Article
- Response: Commentary: Data processing thresholds for abundance and sparsity and missed biological insights in an untargeted chemical analysis of blood specimens for exposomics.Frontiers in public health · 2022Article
- Placental metabolic profiling in gestational diabetes mellitus: An important role of fatty acids.Journal of clinical laboratory analysis · 2021Article
- Cord blood metabolic signatures predictive of childhood overweight and rapid growth.International journal of obesity (2005) · 2021Article
- CANTARE: finding and visualizing network-based multi-omic predictive models.BMC bioinformatics · 2021Article
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Authors and funding
22 authors at 13 institutions in 8 countries.
Funding
Abstract
backgroundBirthweight reflects in utero exposures and later health evolution. Despite existing studies employing high-dimensional molecular measurements, the understanding of underlying mechanisms of birthweight remains limited.
methodsTo investigate the systems biology of birthweight, we cross-sectionally integrated the methylome, the transcriptome, the metabolome and a set of inflammatory proteins measured in cord blood samples, collected from four birth-cohorts (n = 489). We focused on two sets of 68 metabolites and 903 CpGs previously related to birthweight and investigated the correlation structures existing between these two sets and all other omic features via bipartite Pearson correlations.
resultsThis dataset revealed that the set of metabolome and methylome signatures of birthweight have seven signals in common, including three metabolites [PC(34:2), plasmalogen PC(36:4)/PC(O-36:5), and a compound with m/z of 781.0545], two CpGs (on the DHCR24 and SC4MOL gene), and two proteins (periostin and CCL22). CCL22, a macrophage-derived chemokine has not been previously identified in relation to birthweight. Since the results of the omics integration indicated the central role of cholesterol metabolism, we explored the association of cholesterol levels in cord blood with birthweight in the ENVIRONAGE cohort (n = 1097), finding that higher birthweight was associated with increased high-density lipoprotein cholesterol and that high-density lipoprotein cholesterol was lower in small versus large for gestational age newborns.
conclusionsOur data suggests that an integration of different omic-layers in addition to single omics studies is a useful approach to generate new hypotheses regarding biological mechanisms. CCL22 and cholesterol metabolism in cord blood play a mechanistic role in birthweight.
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