Evidence map›Paper›PMID 32553626›Full record

ArticleBiochemical and biophysical research communications2020

Synergistic regulation of hepatic Fsp27b expression by HNF4α and CREBH.

Carlos Ichiro Kasano-Camones, Masayuki Takizawa, Wakana Iwasaki, Shota Sasaki, Mume Hamada, Aoi Morimoto, Masakiyo Sakaguchi, Frank J Gonzalez, Yusuke Inoue

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Carlos Ichiro Kasano-CamonesDivision of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu, Gunma, 376-8515, Japan.
Masayuki TakizawaDivision of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu, Gunma, 376-8515, Japan.
Wakana IwasakiDivision of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu, Gunma, 376-8515, Japan.
Shota SasakiDivision of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu, Gunma, 376-8515, Japan.
Mume HamadaDivision of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu, Gunma, 376-8515, Japan.
Aoi MorimotoDivision of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu, Gunma, 376-8515, Japan.
Masakiyo SakaguchiDepartment of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Frank J GonzalezLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20852, USA.
Yusuke InoueDivision of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu, Gunma, 376-8515, Japan; Gunma University Center for Food Science and Wellness, Maebashi, Gunma, 371-8510, Japan. Electronic address: yinoue@gunma-u.ac.jp.
Gunma University · JPNational Cancer Institute · USOkayama University · JP

Funding

Xenobiotic receptorsZIABC005562 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GONZALEZ, FRANK J · 2009 to 2025
$26.9M
Intramural NIH HHS ZIA BC005562
6 · The paper itself

Abstract

The CIDE (cell death-inducing DFF45-like effector) family composed of CIDEA, CIDEB, CIDEC/FSP27 (fat-specific protein 27), has a critical role in growth of lipid droplets. Of these, CIDEB and CIDEC2/FSP27B are abundant in the liver, and the steatotic livers, respectively. Hepatocyte nuclear factor 4α (HNF4α) has an important role in lipid homeostasis because liver-specific HNF4α-null mice (Hnf4a

Indexed as

Gene Expression RegulationAnimalsCyclic AMP Response Element-Binding ProteinFatty LiverHepatocyte Nuclear Factor 4Hep G2 CellsHumansLiverMiceProteinsTranscriptional ActivationCreb3l3 protein, mouseCyclic AMP Response Element-Binding Proteinfat-specific protein 27, mouseHepatocyte Nuclear Factor 4Hnf4a protein, mouseProteinsCIDE familyCREBHFsp27bHNF4αLiver

Identifiers

PMID32553626
PMCPMC7484291
OpenAlexW3035473561

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.