Evidence map›Paper›PMID 32553173›Full record

ArticleImmunity2020

Single-Cell RNA-Seq Mapping of Human Thymopoiesis Reveals Lineage Specification Trajectories and a Commitment Spectrum in T Cell Development.

Justin Le, Jeong Eun Park, Vi Luan Ha, Annie Luong, Sergio Branciamore, Andrei S Rodin, Grigoriy Gogoshin, Fan Li, Yong-Hwee Eddie Loh, Virginia Camacho and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 95 citations in OpenAlex.

  1. Article
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  12. Development of αβ and γδ T Cells in the Thymus and Methods of Analysis.International journal of molecular sciences · 2025
    Review
  13. Article
  14. Article
  15. Article
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  17. Article
  18. Review
  19. Article
  20. Transcriptional network dynamics in early T cell development.The Journal of experimental medicine · 2024
    Review

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Justin LeCancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Jeong Eun ParkCancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Vi Luan HaCancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Annie LuongCancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Sergio BranciamoreDepartment of Computational and Quantitative Medicine, and Diabetes and Metabolism Research Institute, City of Hope National Medical Center, Duarte, CA, USA.
Andrei S RodinDepartment of Computational and Quantitative Medicine, and Diabetes and Metabolism Research Institute, City of Hope National Medical Center, Duarte, CA, USA.
Grigoriy GogoshinDepartment of Computational and Quantitative Medicine, and Diabetes and Metabolism Research Institute, City of Hope National Medical Center, Duarte, CA, USA.
Fan LiCancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Yong-Hwee Eddie LohUSC Libraries Bioinformatics Services, Los Angeles, CA, USA.
Virginia CamachoDivision of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL, USA.
Sweta B PatelDivision of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL, USA.
Robert S WelnerDivision of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL, USA.
Chintan ParekhCancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA; Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: cparekh@chla.usc.edu.
Children's Hospital of Los Angeles · USCity Of Hope National Medical Center · USUniversity of Alabama at Birmingham · USAssociation of Research Libraries · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Experimental-Computational Synthesis of Altered Immune Signaling in Breast CancerU01CA232216 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI LEE, PETER POON-HANG, ROCKNE, RUSSELL CHRISTIAN · 2019 to 2023
$3.0M
An integrated toolkit combining computational systems biology techniques with molecular dynamics simulations to delineate functionality of GPCRsR01LM013876 · NLM · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI RODIN, ANDREI, VAIDEHI, NAGARAJAN · 2022 to 2025
$1.5M
NCI NIH HHS P30 CA013148NCI NIH HHS U01 CA232216NLM NIH HHS R01 LM013876
6 · The paper itself

Abstract

The challenges in recapitulating in vivo human T cell development in laboratory models have posed a barrier to understanding human thymopoiesis. Here, we used single-cell RNA sequencing (sRNA-seq) to interrogate the rare CD34

Indexed as

AnimalsBiomarkersCell DifferentiationCell LineageComputational BiologyGene Expression ProfilingGene Expression Regulation, DevelopmentalHigh-Throughput Nucleotide SequencingHumansImmunophenotypingLymphopoiesisMiceSingle-Cell AnalysisThymocytesT-LymphocytesTranscriptomeBiomarkersearly thymic progenitorshuman thymopoiesissingle-cell transcriptomesT-lineage commitmentT-lineage specification

Identifiers

PMID32553173
PMCPMC7388724
OpenAlexW3034759084

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.