ArticleCell reports2020
STING Gain-of-Function Disrupts Lymph Node Organogenesis and Innate Lymphoid Cell Development in Mice.
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Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Review
- Interstitial lung disease and the STING pathway.The Journal of clinical investigation · 2026Review
- Activated STING in the thymic epithelium alters T cell development and selection leading to autoimmunity.The Journal of clinical investigation · 2025Article
- Lymphopenia drives T cell exhaustion in immunodeficient STING gain-of-function mice.EMBO molecular medicine · 2025Article
- Article
- Tissue inflammation induced by constitutively active STING is mediated by enhanced TNF signaling.eLife · 2025Article
- Article
- Dynamic STING repression orchestrates immune cell development and function.Science immunology · 2025Article
- Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans.Nature communications · 2024Article
- Endothelial cell expression of a STING gain-of-function mutation initiates pulmonary lymphocytic infiltration.Cell reports · 2024Article
- Type I IFN signaling in the absence of IRGM1 promotesbioRxiv : the preprint server for biology · 2023Article
- Regulation of cGAS and STING signaling during inflammation and infection.The Journal of biological chemistry · 2023Review
- The IFN-γ receptor promotes immune dysregulation and disease in STING gain-of-function mice.JCI insight · 2022Article
- The transmembrane endoplasmic reticulum-associated E3 ubiquitin ligase TRIM13 restrains the pathogenic-DNA-triggered inflammatory response.Science advances · 2022Article
- Review
- Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy.Frontiers in immunology · 2022Review
- Dysregulation of the cGAS-STING Pathway in Monogenic Autoinflammation and Lupus.Frontiers in immunology · 2022Review
- The cGAS-STING pathway as a therapeutic target in inflammatory diseases.Nature reviews. Immunology · 2021Review
- STING-Mediated Lung Inflammation and Beyond.Journal of clinical immunology · 2021Review
- Lymphoid Tissue inducer (LTi) cell ontogeny and functioning in embryo and adult.Biomedical journal · 2021Review
Corrections and comments
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Authors and funding
22 authors at 8 institutions in 3 countries.
Brock G BennionDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Carys A CroftInnate Immunity Unit, Institut Pasteur, Paris, France; INSERM U1223, Institut Pasteur, Paris, France; Université de Paris, Sorbonne Paris Cité, Paris, France.
Teresa L AiDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Wei QianDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Amber M MenosDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Cathrine A MinerDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Marie-Louis FrémondDepartment of Hematology and Rheumatology, Necker-Enfants Malades Hospital, APHP, Paris, France.
Jean-Marc DoisneInnate Immunity Unit, Institut Pasteur, Paris, France; INSERM U1223, Institut Pasteur, Paris, France.
Prabhakar S AndheyDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Derek J PlattDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Jennifer K BandoDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Erin R WangDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Hella LukschDepartment of Pediatrics, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Thierry J MolinaUniversité de Paris, Department of Pathology, Necker-Enfants Malades Hospital, Paris, France.
Elisha D O RobersonDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Genetics, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Maxim N ArtyomovDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Angela Rösen-WolffDepartment of Pediatrics, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Frédéric Rieux-LaucatUniversité de Paris, Institut Imagine, Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, INSERM UMR 1163, 75015 Paris, France.
James P Di SantoInnate Immunity Unit, Institut Pasteur, Paris, France; INSERM U1223, Institut Pasteur, Paris, France.
Bénédicte NevenDepartment of Hematology and Rheumatology, Necker-Enfants Malades Hospital, APHP, Paris, France; Université de Paris, Institut Imagine, Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, INSERM UMR 1163, 75015 Paris, France. Electronic address: benedicte.neven@nck.aphp.fr.
Jonathan J MinerDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address: jonathan.miner@wustl.edu.
Washington University in St. Louis · USInstitut Pasteur · FRUniversité Paris Cité · FRAssistance Publique – Hôpitaux de Paris · FRHôpital Necker-Enfants Malades · FRInserm · FRTU Dresden · DEUniversity Hospital Carl Gustav Carus · DE
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0MWU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MNATIONAL RESEARCH SERVICE AWARD-MEDICAL SCIENTISTT32GM007200 · NIGMS · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 1985 to 2024
$59.8MWashington University Rheumatic DiseasesResearch Resource-based CenterP30AR073752 · NIAMS · WASHINGTON UNIVERSITY · PI Christine T. Pham · 2018 to 2026
$7.6MMechanisms of STING-associated immunodeficiencyR01AI143982 · NIAID · WASHINGTON UNIVERSITY · PI Jonathan J Miner · 2019 to 2026
$4.6MMAXIMIZING STUDENT DIVERSITY IN THE BIOMEDICAL SCIENCES AT WASHINGTON UNIVERSITYR25GM103757 · NIGMS · WASHINGTON UNIVERSITY · PI SKEATH, JAMES BENJAMIN · 2013 to 2022
$4.5MContributions of IRF5 to Chikungunya Viral ArthritisK08AR070918 · NIAMS · WASHINGTON UNIVERSITY · PI MINER, JONATHAN J · 2017 to 2021
$612kImmune Checkpoints for Intestinal Innate Lymphoid CellsK99DK118110 · NIDDK · WASHINGTON UNIVERSITY · PI BANDO, JENNIFER KAORU · 2019 to 2020
$182kNCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NIAID NIH HHS R01 AI143982NIAMS NIH HHS K08 AR070918NIAMS NIH HHS P30 AR073752NIDDK NIH HHS K99 DK118110NIGMS NIH HHS R25 GM103757NIGMS NIH HHS T32 GM007200
Abstract
STING gain-of-function causes autoimmunity and immunodeficiency in mice and STING-associated vasculopathy with onset in infancy (SAVI) in humans. Here, we report that STING gain-of-function in mice prevents development of lymph nodes and Peyer's patches. We show that the absence of secondary lymphoid organs is associated with diminished numbers of innate lymphoid cells (ILCs), including lymphoid tissue inducer (LTi) cells. Although wild-type (WT) α4β7
Indexed as
AnimalsCell DifferentiationGain of Function MutationImmunity, InnateLymph NodesLymphocytesLymphoid TissueMiceOrganogenesisT-Lymphocytes, Helper-InducerILCinnate lymphoid cellLTi celllymph nodelymphoid tissue organogenesislymphopoiesisPeyer's patchSAVISTINGSTING-associated vasculopathy with onset in infancy
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.