Evidence map›Paper›PMID 32552911›Full record

Observational studyInternational breastfeeding journal2020

Effects of perinatal factors on sirtuin 3, 8-hydroxy-2'- deoxyguanosine, brain-derived neurotrophic factor and serotonin in cord blood and early breast milk: an observational study.

Kata Nyárády, Réka Turai, Simone Funke, Erzsébet Györgyi, Alexandra Makai, Viktória Prémusz, József Bódis, Endre Sulyok

Open access · goldAbstract readComparative StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International breastfeeding journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Kata NyárádyDoctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary.
Réka TuraiDepartment of Obstetrics and Gynaecology, Medical School, University of Pécs, Pécs, Hungary.
Simone FunkeDepartment of Obstetrics and Gynaecology, Medical School, University of Pécs, Pécs, Hungary.
Erzsébet GyörgyiDepartment of Laboratory Medicine, Medical School, University of Pécs, Ifjúság u. 13, Pécs, H-7624, Hungary.
Alexandra MakaiDoctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary.
Viktória PrémuszDoctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary. premusz.viktoria@pte.hu.ORCID 0000-0002-4059-104X
József BódisDepartment of Obstetrics and Gynaecology, Medical School, University of Pécs, Pécs, Hungary.
Endre SulyokDoctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary.
University of Pecs · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe profile of sirtuin 3 (SIRT3), 8-hydroxy-2'-deoxyguanosine (8-OHdG), brain-derived neurotrophic factor (BDNF) and serotonin (5-HT) in cord blood and in early breast milk was studied and it was related to perinatal factors. 5-HT and BDNF signalling systems have been claimed to play a critical role in intrauterine development, postnatal adaptation and lactation. Since prematurity and Caesarean birth are frequently associated with inflammation and related oxidative stress, an attempt was made to reveal the adaptive changes of the protective SIRT3 and the complex interplay among these bioactive components in cord blood and early breast milk.

methodsThree groups each consisting of 30 mothers were included in the study: mothers who underwent spontaneous vaginal birth at term (group I), Caesarean section at term (group II) and preterm birth (group III). Venous cord blood and early breast milk samples were collected for measuring the biomarkers. SIRT3, 8-OHdG, BDNF and 5-HT levels were determined by using commercially available ELISA kits.

resultsIt was demonstrated that cord blood levels of SIRT3, BDNF and 5-HT were markedly reduced whereas those of 8-OHdG were significantly elevated after preterm birth when compared with birth at term. The Caesarean section was associated with a moderate decrease in BDNF and 5-HT, however, both SIRT3 and 8-OHdG remained unaffected. Breast milk levels of all biomarkers studied proved to be independent of their corresponding cord blood concentrations. In response to preterm birth breast milk SIRT3, 8-OHdG and 5-HT increased significantly, while a drastic fall occurred in BDNF. A significant positive relationship was found of 5-HT with SIRT3 and 8-OHdG irrespective of the gestational age and the mode of delivery.

conclusionsIt is suggested that the selected biomarkers in the breast milk mostly derive from local production by the mammary glands and 5-HT may have an essential role in the control of this process.

Indexed as

8-Hydroxy-2'-DeoxyguanosineAdultBiomarkersBrain-Derived Neurotrophic FactorBreast FeedingCesarean SectionDelivery, ObstetricFemaleFetal BloodHumansHungaryInfant, NewbornMilk, HumanParturitionPregnancyPremature Birth8-Hydroxy-2'-DeoxyguanosineBiomarkersBrain-Derived Neurotrophic FactorSerotoninSirtuin 38-hydroxy-2′-deoxyguanosineBrain-derived neurotrophic factorBreast milkCord bloodSerotoninSirtuin

Identifiers

PMID32552911
PMCPMC7302386
OpenAlexW3036523170

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.