Evidence map›Paper›PMID 32552908›Full record

ArticleBMC research notes2020

Immunohistochemical expression of Cyclin D1 among Sudanese patients diagnosed with benign and malignant prostatic lesions.

Eiman Siddig Ahmed, Lubna S Elnour, Rowa Hassan, Emmanuel E Siddig, Mintu Elsa Chacko, Eman T Ali, Mona A Mohamed, Abdalla Munir, Mohamed S Muneer, Nouh S Mohamed and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Eiman Siddig AhmedMycetoma Research Center, University of Khartoum, Khartoum, Sudan.
Lubna S ElnourDepartment of Cytology and Histopathology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.
Rowa HassanMycetoma Research Center, University of Khartoum, Khartoum, Sudan.
Emmanuel E SiddigMycetoma Research Center, University of Khartoum, Khartoum, Sudan.
Mintu Elsa ChackoFaculty of Medicine, National University, Khartoum, Sudan.
Eman T AliDepartment of Cytology and Histopathology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.
Mona A MohamedDepartment of Parasitology and Medical Entomology, Faculty of Medical Laboratory Sciences, Nile University, Khartoum, Sudan.
Abdalla MunirDepartment of Bioinformatics and Biostatistics, National University Research Institute, National University, Khartoum, Sudan.
Mohamed S MuneerDepartment of Neurology, Mayo Clinic, Jacksonville, FL, USA.
Nouh S MohamedDepartment of Parasitology and Medical Entomology, Faculty of Medical Laboratory Sciences, Nile University, Khartoum, Sudan. nouh_saad@outlook.com.ORCID http://orcid.org/0000-0001-6843-3361
Ali M M EdrisDepartment of Cytology and Histopathology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.
University of Khartoum · SDNational University · SDUniversity of Medical Sciences and Technology · SD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesProstate cancer (PC) is common cancer worldwide. Several markers have been developed to differentiate between benign prostatic hyperplasia (BPH) from PC. A descriptive retrospective hospital-based study aimed at determining the expression of Cyclin D1 in BPH and PC. The study took place at different histopathology laboratories in Khartoum state, Sudan, from December 2016 to January 2019. Formalin-fixed paraffin-embedded blocks were sectioned and fixed in 3-aminopropyltriethoxysilane coated slides incubated into primary antibody for Cyclin D1. The assessment of immunoreactivity of Cyclin D1 of each section was done using the Gleason scoring system.

resultsA total of 153 males' prostate sections included in this study, of them, 120 (78.4%) were PC, and 33 (21.6%) were BPH. Their age ranged from 45 to 88 years, mean age was 66.19 ± 8.599. 142 (92.8%) did not have a family history of PC, while 11 (7.2%) patients reported having a family history. The Gleason scoring showed a total of 81 (52.9%) patients with high-grade and 39 (25.5%) with low-grade. 118 (97.5%) patients had PC showed positive results for Cyclin D1, while BPH was 3 (2.5%). P value < 0.001. Cyclin D1 staining was associated with high-grade Gleason score and perineural invasion, P value 0.001.

Indexed as

AgedAged, 80 and overCyclin D1HumansImmunohistochemistryMaleMiddle AgedNeoplasm GradingProstatic HyperplasiaProstatic NeoplasmsRetrospective StudiesSudanCCND1 protein, humanCyclin D1Cyclin D1Immunohistochemical expressionPrognostic markersProstate cancer

Identifiers

PMID32552908
PMCPMC7302005
OpenAlexW3036033702

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.