ArticleJournal of cardiothoracic surgery2020
Surgical ligation of patent ductus arteriosus in preterm neonates weighing less than 1500g: a 9-year single center experience.
Article in Journal of cardiothoracic surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 21 citations in OpenAlex.
- Bedside patent ductus arteriosus ligation via anterior mini-thoracotomy in preterm infants weighing ≤ 1500 g: a retrospective cohort study.Journal of cardiothoracic surgery · 2026Article
- Identifying Factors Associated with Prolonged Postoperative Mechanical Ventilation in Preterm Infants Undergoing Patent Ductus Arteriosus Ligation Using Machine Learning and SHAP Analysis: A Large-Sample Single-Center Retrospective Analysis.Journal of clinical medicine · 2026Article
- The association between patent ductus arteriosus and adverse outcomes in preterm infants.BMC pediatrics · 2026Article
- Safety and Effectiveness of the KA Micro Plug for Treatment of Patent Ductus Arteriosus in Preterm Low-Birth-Weight Infants: Retrospective Analysis From a Multicenter Registry.Journal of the Society for Cardiovascular Angiography & Interventions · 2026Article
- Case Report: Comprehensive management of bedside ligation of patent ductus arteriosus in an extremely low birth weight infant.Frontiers in cardiovascular medicine · 2026Article
- Characteristics of neonatal necrotizing enterocolitis in relation to the presence or absence of patent ductus arteriosus.BMC pregnancy and childbirth · 2025Article
- Factors affecting length of stay according to bronchopulmonary dysplasia severity: a nationwide cohort study in Korea.World journal of pediatrics : WJP · 2024Article
- [Risk factors for the failure of ibuprofen treatment in preterm infants with hemodynamically significant patent ductus arteriosus].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Utility of Follow-Up Echocardiograms in Uncomplicated PDA Device Closures Performed During Infancy.Cardiology and therapy · 2022Article
- Utility of Follow-Up Echocardiograms in Uncomplicated PDA Device Closures Performed After Infancy.Cardiology and therapy · 2022Article
- Discriminant Analysis of Main Prognostic Factors Associated with Hemodynamically Significant PDA: Apgar Score, Silverman-Anderson Score, and NT-Pro-BNP Level.Journal of clinical medicine · 2021Article
- Patent ductus arteriosus treatment trends and associated morbidities in neonates.Scientific reports · 2021Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to determine the feasibility and outcomes of early surgical ligation in preterm neonates with hemodynamically significant patent ductus arteriosus (HSPDA) and to investigate predictors for surgical treatment after unsuccessful medical management.
methodsMedical records from the neonatal intensive care unit of Hanyang University Seoul Hospital from January 2010 to December 2018 were retrospectively reviewed. 233 preterm neonates weighing less than 1500g with HSPDA were enrolled in our study. Of these preterm neonates, 134 underwent surgical ligation and were subdivided into the early ligation group (n = 49; within 10 days of age) and the late ligation group (n = 85; after 10 days of age).
resultsThe mean gestational age and birth weight were significantly lower in the patent ductus arteriosus (PDA) ligation group than in the Non-ligation group (p < 0.001). PDA ductal diameter > 2.0 mm (p < 0.001), low Apgar score at 5 min (p = 0.033), and chorioamnionitis (p = 0.037) were the predictors for receiving surgical treatment for PDA. Early ligation was significantly associated with a low incidence of culture-proven sepsis (p = 0.004), mechanical ventilator time > 4 weeks (p = 0.007), necrotizing enterocolitis stage (NEC) ≥ III (p = 0.022), and intraventricular hemorrhage (IVH) grade ≥ III (p = 0.035).
conclusionsEarly surgical ligation minimizes the adverse effects of HSPDA in predicted preterm neonates who subsequently require surgical treatment for PDA. This result suggests that in preterm neonates weighing less than 1500g with HSPDA that is unresponsive to medical treatment, delayed ductal closure should be avoided to reduce severe NEC, severe IVH, culture-proven sepsis, and facilitate earlier endotracheal extubation.
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