ArticleBMC plant biology2020
Comparative transcriptome analysis of mulberry reveals anthocyanin biosynthesis mechanisms in black (Morus atropurpurea Roxb.) and white (Morus alba L.) fruit genotypes.
Article in BMC plant biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 54 citations in OpenAlex.
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- Lipid-lowering activity of mulberry seed unsaturated fatty acids: integrating network pharmacology and experimental validation.Functional & integrative genomics · 2026Article
- Effect ofLife (Basel, Switzerland) · 2026Article
- Environmental control of anthocyanin biosynthesis in mulberry: unraveling gene networks for food applications.Food chemistry. Molecular sciences · 2026Review
- Genomics-Driven Mulberry Breeding for Improving Agronomic Traits and Circular Utilization Value.Biology · 2026Review
- ATAC-Seq and RNA-Seq Integration Reveals Chromatin Accessibility and Transcriptional Dynamics During Fruit Color Development in Mulberry.International journal of molecular sciences · 2026Article
- Integrated Transcriptomic and Metabolomic Analysis of Color Changes in Maize Root Systems Treated with Methyl Jasmonate.Biology · 2025Article
- UV radiation promotes anthocyanins biosynthesis in the fruit peel of blood oranges (Frontiers in plant science · 2025Article
- Article
- Haplotype-resolved chromosomal-level genome assembly reveals regulatory variations in mulberry fruit anthocyanin content.Horticulture research · 2024Article
- Transcriptomic and metabolic analysis unveils the mechanism behind leaf color development inFrontiers in molecular biosciences · 2024Article
- Phylogenetic relationship and sequence diversity of candidate genes involved in anthocyanin biosynthesis pathway inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2023Article
- Enhancement of Stability and Antioxidant Activity of Mulberry Anthocyanins Through Succinic Acid Acylation.Food technology and biotechnology · 2022Article
- The Ethylene Response Factor ERF5 Regulates Anthocyanin Biosynthesis in 'Zijin' Mulberry Fruits by Interacting withInternational journal of molecular sciences · 2022Article
- Identification of microRNAs and their target genes related to the accumulation of anthocyanin in purple potato tubers (Plant direct · 2022Article
- Adaptation insights from comparative transcriptome analysis of two Opisthopappus species in the Taihang mountains.BMC genomics · 2022Article
- Comparative Transcriptome Analysis of Purple and Green Non-Heading Chinese Cabbage and Function Analyses ofGenes · 2022Article
- Functional Characterization of Flavanone 3-Hydroxylase (F3H) and Its Role in Anthocyanin and Flavonoid Biosynthesis in Mulberry.Molecules (Basel, Switzerland) · 2022Article
- Integrative Analysis of Metabolome and Transcriptome Reveals the Mechanism of Color Formation inMetabolites · 2022Article
- Plant-derived compounds effectively inhibit the main protease of SARS-CoV-2: An in silico approach.PloS one · 2022Article
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7 authors at 2 institutions in 1 country.
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Abstract
backgroundTo gain a better understanding of anthocyanin biosynthesis in mulberry fruit, we analyzed the transcriptome of the mulberry varieties Da 10 (Morus atropurpurea Roxb., black fruit) and Baisang (Morus alba L., white fruit).
resultsWe found that whereas Da 10 had high levels of cyanidin 3-O-glucoside (Cy), and pelargonidin 3-O-glucoside (Pg), Baisang contained only Cy, at low levels. Based on a comparative transcriptome analysis, we annotated more than 27,085 genes (including 1735 new genes). Genes that were differentially expressed between Da 10 and Baisang were detected at three stages of fruit development: S1 [4256 genes, 10 days post-anthesis (DPA)], S2 (5612 genes, 19 DPA), and S3 (5226 genes, 28 DPA). Anthocyanin biosynthesis was found to be associated with the expression of 15 core genes and 5 transcription factors. Relative to Baisang, Da 10 showed a significant upregulation of genes involved in the early stages (production of the intermediate compounds chalcone and dihydroflavonol) and late stages (production of Cy and Pg) of anthocyanin biosynthesis. Baisang showed a significant downregulation of the genes involved in the early stages of anthocyanin biosynthesis and overexpression of flavanone 3-hydroxylase (FLS), resulting in the generation of quercetin and/or myricetin but not anthocyanins.
conclusionsThe biosynthesis of anthocyanin in mulberry fruit is initiated from the precursor, phenylalanine, and mediated by the upregulation of dihydroflavonol 4-reductase, anthocyanidin synthase, anthocyanidin 3-O-glucosyltransferase, and cyanidin-3-O-glucoside 2-O-glucuronosyltransferase, and downregulation of FLS to produce Cy and Pg.
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