GuidelineUnited European gastroenterology journal2020
European Guideline on IgG4-related digestive disease - UEG and SGF evidence-based recommendations.
Guideline in United European gastroenterology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06328101 (A Multicenter, Retrospective Study on Autoimmune Pancreatitis, Pancreatic and Extrapancreatic cAnceR), which is not on this map. Cited by 116 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multicenter, Retrospective Study on Autoimmune Pancreatitis, Pancreatic and Extrapancreatic cAnceR (AiPPEAR)
Who cites it
116 citing papers in PubMed, 3 syntheses or guidelines pooled it, 222 citations in OpenAlex.
- European guidelines for the diagnosis and treatment of pancreatic exocrine insufficiency: UEG, EPC, EDS, ESPEN, ESPGHAN, ESDO, and ESPCG evidence-based recommendations.United European gastroenterology journal · 2025Guideline
- IgG4-related disorders of the gastrointestinal tract: Experience from a tertiary care centre with systematic review of Indian literature.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Pooled it
- Unraveling the relationship between autoimmune pancreatitis type 2 and inflammatory bowel disease: Results from two centers and systematic review of the literature.United European gastroenterology journal · 2022Pooled it
- Type 3 Autoimmune Pancreatitis: What Do We Know So Far?Digestive diseases and sciences · 2026Review
- PSC-DM: A Validated Clinical Diagnostic Model for Distinguishing Primary From Secondary Sclerosing Cholangitis.Liver international : official journal of the International Association for the Study of the Liver · 2026Article
- IgG4-related disease in gastroenterology: from pathogenesis to clinical management and long-term outcomes.Journal of gastroenterology · 2026Review
- Nationwide epidemiological survey of autoimmune pancreatitis in Japan in 2021.Journal of gastroenterology · 2026Article
- A case report: an unusual case of ulcerative intestinal IgG4-related disease with clinical features overlapping with probable intestinal Behcet's disease.BMC gastroenterology · 2026Article
- Article
- Article
- Impact of Steroid Pulse Therapy on Early Treatment Response and Relapse in Type 1 Autoimmune Pancreatitis.JGH open : an open access journal of gastroenterology and hepatology · 2026Article
- Diagnostic Imaging of Pancreatic and Biliary Involvement in IgG4-Related Disease: Key Imaging Features, Diagnostic Criteria and Differential Diagnosis.Diagnostics (Basel, Switzerland) · 2026Review
- IgG4-related autoimmune pancreatitis mimicking a degenerating intraductal papillary mucinous neoplasm.Endoscopy · 2026Article
- Endoscopically-detected small-intestinal lesions with dense infiltration of IgG4-positive plasma-cells.Clinical journal of gastroenterology · 2026Article
- Multifocal Autoimmune Pancreatitis Mimicking Pancreatic Neoplasm in a Young Adult: A Diagnostic Challenge.Cureus · 2026Article
- Management of IgG4-Related Disease.Current rheumatology reports · 2026Review
- Article
- Development and validation of a clinical-radiomics nomogram for the differential diagnosis of focal pancreatic solid lesions: a retrospective cohort study.Translational cancer research · 2026Article
- Article
- Case Report: Recurrent abdominal pain with elevated pancreatic enzymes in type 2 diabetes mellitus: a case of IgG4-related autoimmune pancreatitis misdiagnosed as acute pancreatitis.Frontiers in endocrinology · 2026Article
56 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
36 authors at 20 institutions in 14 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The overall objective of these guidelines is to provide evidence-based recommendations for the diagnosis and management of immunoglobulin G4 (IgG4)-related digestive disease in adults and children. IgG4-related digestive disease can be diagnosed only with a comprehensive work-up that includes histology, organ morphology at imaging, serology, search for other organ involvement, and response to glucocorticoid treatment. Indications for treatment are symptomatic patients with obstructive jaundice, abdominal pain, posterior pancreatic pain, and involvement of extra-pancreatic digestive organs, including IgG4-related cholangitis. Treatment with glucocorticoids should be weight-based and initiated at a dose of 0.6-0.8 mg/kg body weight/day orally (typical starting dose 30-40 mg/day prednisone equivalent) for 1 month to induce remission and then be tapered within two additional months. Response to initial treatment should be assessed at week 2-4 with clinical, biochemical and morphological markers. Maintenance treatment with glucocorticoids should be considered in multi-organ disease or history of relapse. If there is no change in disease activity and burden within 3 months, the diagnosis should be reconsidered. If the disease relapsed during the 3 months of treatment, immunosuppressive drugs should be added.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.