ArticleJournal of the American Heart Association2020
Cerebral Blood Flow-Guided Manipulation of Arterial Blood Pressure Attenuates Hippocampal Apoptosis After Asphyxia-Induced Cardiac Arrest in Rats.
Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 11 citations in OpenAlex.
- Positive Impact of Holistic Nursing on Cognitive Impairment and Psychiatric Symptoms in Patients With Alzheimer's Disease.Actas espanolas de psiquiatria · 2025Trial
- Morphological Changes in the Rat Brain in the Early Post-Resuscitation Period: The Relationship Between Hypoxia-Sensitive Immunohistochemical Markers, Hemodynamic and Acid-Base Status.International journal of molecular sciences · 2026Article
- Effects of Intrathecal Magnesium Administration on Neurologic Outcomes in a Porcine Model of Asphyxial Cardiac Arrest.Journal of the American Heart Association · 2026Article
- Prognostic implication of heart failure stage and left ventricular ejection fraction for patients with in-hospital cardiac arrest: a 16-year retrospective cohort study.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Crosstalk Among Glial Cells in the Blood-Brain Barrier Injury After Ischemic Stroke.Molecular neurobiology · 2024Review
- Optimal inhaled oxygen and carbon dioxide concentrations for post-cardiac arrest cerebral reoxygenation and neurological recovery.iScience · 2023Article
- Assessment of the Effects of Sodium Nitroprusside Administered Via Intracranial Subdural Catheters on the Cerebral Blood Flow and Lactate Using Dynamic Susceptibility Contrast Magnetic Resonance Imaging and Proton Magnetic Resonance Spectroscopy in a Pig Cardiac Arrest Model.Journal of the American Heart Association · 2023Article
- Inhaled Carbon Dioxide Improves Neurological Outcomes by Downregulating Hippocampal Autophagy and Apoptosis in an Asphyxia-Induced Cardiac Arrest and Resuscitation Rat Model.Journal of the American Heart Association · 2022Article
- Rat model of asphyxia-induced cardiac arrest and resuscitation.Frontiers in neuroscience · 2022Review
- Cerebral Blood Flow-Guided Manipulation of Arterial Blood Pressure Attenuates Hippocampal Apoptosis After Asphyxia-Induced Cardiac Arrest in Rats.Journal of the American Heart Association · 2020Article
- Supplement of Lipid Emulsion to Epinephrine Improves Resuscitation Outcomes of Asphyxia-Induced Cardiac Arrest in Aged Rats.Clinical interventions in aging · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background In most post-cardiac arrest patients, the autoregulation mechanism of cerebral blood flow (CBF) is dysregulated. We examined whether recovery of CBF by adjusting mean arterial pressure mitigates post-cardiac arrest neuronal damage. Methods and Results Wistar rats that underwent 8-minute asphyxia-induced cardiac arrest and resuscitation were computer-randomized to norepinephrine or control groups. The CBF was measured at the dorsal hippocampal CA1 region of the left hemisphere. In the norepinephrine group, the mean arterial pressure was adjusted to recover CBF to 80% to 100% of baseline. Twenty-four hours following resuscitation, neurological outcomes were assessed, and brain tissues and blood samples were harvested for neuronal apoptosis and injury assessment. Thirty resuscitated rats were randomized into 2 groups, each containing 12 rats that completed the experiments. Norepinephrine infusion effectively prevented posthyperemia hypoperfusion and recovered CBF to pre-arrest baseline levels; a moderate positive linear correlation between mean arterial pressure and CBF during this period was also observed (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.