Evidence map›Paper›PMID 32551947›Full record

SynthesisCartilage2021

PRP Injections for the Treatment of Knee Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials.

Giuseppe Filardo, Davide Previtali, Francesca Napoli, Christian Candrian, Stefano Zaffagnini, Alberto Grassi

5 registry-linked trialsOpen access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cartilage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 149 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
149citing papers in PubMed, 15 pooled it
28.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05657496 phase1 / phase2terminatednot on this mapstarted 2022, after this paper: background citation

Biological Response to Platelet-rich Plasma and Corticosteroid Injections

TypeinterventionalSponsorUniversity of Missouri-ColumbiaRan2022 to 2025Enrolled23ConditionsKnee OsteoarthritisArmsTriamcinolone Acetonide 40 mg/ml Inj, Susp, Platelet-rich plasma Inj
NCT06032039 early_phase1unknown statusnot on this mapstarted 2023, after this paper: background citation

Corticosteroid vs Platelet-Rich Plasma Intra-articular Injections in the Treatment of Knee Osteoarthritis in Patients Fifty Years and Older: a Look at Pain and Functional Outcomes at a Single Institution.

TypeinterventionalSponsorThe University of The West IndiesRan2023 to 2025Enrolled160ConditionsKnee OsteoarthritisArmsTriamcinolone, Platelet Rich Plasma
NCT06122116 naterminatednot on this mapstarted 2023, after this paper: background citation

Investigating Orthobiologics After Platelet-Rich Plasma and Photobiomodulation Treatment of Knee Osteoarthritis

TypeinterventionalSponsorMusculoskeletal Injury Rehabilitation Research for Operational ReadinessRan2023 to 2024Enrolled33ConditionsKnee OsteoarthritisArmsPhysical Therapy, Platelet-Rich Plasma Injection, Photobiomodulation Therapy
NCT06415461 phase1active not recruitingnot on this mapstarted 2024, after this paper: background citation

A Phase 1, Open Label Dose-Ranging Study to Assess the Safety, Tolerability, Preliminary Efficacy, and Dose Effect of CFL001 Cord Blood Product in Patients With Symptomatic Sacroiliac Joint Syndrome

TypeinterventionalSponsorUniversity of FloridaRan2024 to 2028Enrolled9ConditionsSacroiliac, Backache, Pain, BackArmsPremierMaxCB®-Platinum (CFL001)
NCT06685120 narecruitingnot on this mapstarted 2025, after this paper: background citation

Combined Use of PRP and Hyaluronic Acid for Infiltrative Treatment of Patients With Knee Osteoarthritis - Randomized Controlled Clinical Study

TypeinterventionalSponsorIstituto Ortopedico RizzoliRan2025 to 2029Enrolled288ConditionsOsteo Arthritis KneeArmsPRP + HA injection, PRP injection, HA injection
3 · Its place in the literature

Who cites it

149 citing papers in PubMed, 15 syntheses or guidelines pooled it, 271 citations in OpenAlex.

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  10. Management of hip osteoarthritis: harnessing the potential of mesenchymal stem cells-a systematic review.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024
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  12. Platelet-rich plasma injections induce disease-modifying effects in the treatment of osteoarthritis in animal models.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021
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89 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Giuseppe FilardoIRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Davide PrevitaliOspedale Regionale di Lugano, Lugano, Switzerland.ORCID 0000-0002-0284-4368
Francesca NapoliOspedale Regionale di Lugano, Lugano, Switzerland.
Christian CandrianOspedale Regionale di Lugano, Lugano, Switzerland.
Stefano ZaffagniniIRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Alberto GrassiIRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Ospedale regionale di Lugano · CHIstituto Ortopedico Rizzoli · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate effectiveness, in terms of patient-reported outcome measures, of platelet-rich plasma (PRP) injections for knee osteoarthritis compared to placebo and other intraarticular treatments.

designPubMed, Cochrane Library, Scopus, Embase, Web of Science, as well as the gray literature were searched on January 17, 2020. Randomized controlled trials (RCTs) comparing PRP injections with placebo or other injectable treatments, in any language, on humans, were included. Risk of bias was assessed following the Cochrane guidelines; quality of evidence was graded using the GRADE guidelines.

resultsThirty-four RCTs, including 1403 knees in PRP groups and 1426 in control groups, were selected. WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) score favored PRP, with a statistically and clinically significant difference versus placebo at 12-month follow-up (

conclusionsThe effect of platelet concentrates goes beyond its mere placebo effect, and PRP injections provide better results than other injectable options. This benefit increases over time, being not significant at earlier follow-ups but becoming clinically significant after 6 to 12 months. However, although substantial, the improvement remains partial and supported by low level of evidence. This finding urges further research to confirm benefits and identify the best formulation and indications for PRP injections in knee OA.

Indexed as

Osteoarthritis, KneePlatelet-Rich PlasmaHumansInjections, Intra-ArticularRandomized Controlled Trials as TopicTreatment Outcomehyaluronic acidknee osteoarthritismeta-analysisplaceboplatelet-rich plasmaPRPsteroids

Identifiers

PMID32551947
PMCPMC8808870
OpenAlexW3036835022

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.