ArticleAmerican journal of rhinology & allergy2021
Sinus Development and Pneumatization in a Primary Ciliary Dyskinesia Cohort.
Article in American journal of rhinology & allergy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- The development of paranasal sinuses in patients with cystic fibrosis: sinuses volume analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Sinonasal quality of life in primary ciliary dyskinesia.International forum of allergy & rhinology · 2023Article
- Ear and upper airway clinical outcome measures for use in primary ciliary dyskinesia research: a scoping review.European respiratory review : an official journal of the European Respiratory Society · 2023Article
- Primary Ciliary Dyskinesia.CHEST pulmonary · 2023Review
- Sinonasal disease among patients with primary ciliary dyskinesia: an international study.ERJ open research · 2023Article
- Chronic Rhinosinusitis: T2r38 Genotyping and Nasal Cytology in Primary Ciliary Dyskinesia.The Laryngoscope · 2023Article
- Computed Tomography Evaluation of the Paranasal Sinuses in Adults with Primary Ciliary Dyskinesia.International archives of otorhinolaryngology · 2023Article
- Nasal Polyps in Children: The Early Origins of a Challenging Adulthood Condition.Children (Basel, Switzerland) · 2021Review
- Current and Future Treatments in Primary Ciliary Dyskinesia.International journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPrimary ciliary dyskinesia (PCD) is a genetically diverse disease which causes impaired mucociliary clearance, and results in pulmonary, otologic, and rhinologic disease in affected patients. Genetic mutations in multiple genes impair the ability of patients to clear mucous from the lungs, middle ear, and sinonasal cavity and lead to chronic pulmonary and sinonasal symptoms.
methodsWe identified 17 PCD patients who had available CT scans. Volumes for bilateral maxillary, sphenoid, and frontal sinuses were calculated. A control population of patients who had preoperative CT scans for endoscopic endonasal resection of skull base pathology without sinonasal cavity involvement was also identified.
resultsThe mean age of PCD was 33 and ranged from 13 to 54 years. Patients were age- and gender-matched to a control group that underwent resection of anterior skull-base tumors and had a mean age of 35 that ranged between 17-53 years old. The volumes for all thee sinus cavities were significantly smaller (p < 0.007) compared to the control population. The average Lund-Mackay score was 10.6 in the PCD cohort (range 6-16) in comparison to an average of 0.7 in the control cohort (range 0-2).
conclusionsOverall sinus volumes were smaller in patients with PCD compared to our control population. Future studies will be aimed at understanding defects in sinus development as a function of specific genetic mutations in PCD patients. Ultimately, a better understanding of the underlying pathophysiology of PCD will allow us to identify the optimal treatment practices for this unique patient group.
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