Evidence map›Paper›PMID 32551856›Full record

ArticleAmerican journal of physiology. Cell physiology2020

Cholinergic-induced anion secretion in murine jejunal enteroids involves synergy between muscarinic and nicotinic pathways.

Kelli Johnson, Jianyi Yin, Julie G In, Subhash Kulkarni, Pankaj Pasricha, Chung Ming Tse, Mark Donowitz

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. EMC3 is critical for CFTR function and calcium mobilization in the mouse intestinal epithelium.American journal of physiology. Gastrointestinal and liver physiology · 2025
    Article
  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kelli JohnsonDepartment of Cellular and Molecular Physiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland.ORCID 0000-0002-2407-2039
Jianyi YinDivision of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland.
Julie G InDivision of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland.
Subhash KulkarniDivision of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland.ORCID 0000-0002-2298-0623
Pankaj PasrichaDivision of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland.
Chung Ming TseDivision of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland.
Mark DonowitzDepartment of Cellular and Molecular Physiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland.
Johns Hopkins Hospital · USJohns Hopkins University · US

Funding

Translational Research Enhancement CoreP30DK089502 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI POTTER, JAMES JOHN · 2011 to 2020
$12.0M
Translational Approaches to Develop Drug Therapy for DiarrheaR24DK099803 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK · 2014 to 2019
$8.9M
Mechanisms and Correction of Abnormal Bicarbonate Secretion by DRA in DiarrheaR01DK116352 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI TSE, CHUNG-MING · 2019 to 2022
$2.2M
Human Enteroids as a Model of Host-EHEC InteractionsK01DK106323 · NIDDK · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI IN, JULIE GOEUN · 2016 to 2020
$711k
Olympus FluoView3000RS Confocal MicroscopeS10OD025244 · OD · JOHNS HOPKINS UNIVERSITY · PI O'ROURKE, BRIAN · 2018 to 2018
$448k
NIDDK NIH HHS K01 DK106323NIDDK NIH HHS R01 DK116352NIDDK NIH HHS R24 DK099803NIH HHS 1S10OD025244NIH HHS S10 OD025244NIH NIDDK P30DK089502
6 · The paper itself

Abstract

Acetylcholine induces robust electrogenic anion secretion in mammalian intestine and it has long been hypothesized that it mediates the epithelial response through the M

Indexed as

AcetylcholineAnimalsAnionsAtropineCholinergic AgonistsEnterocytesHexamethoniumHumansIntestinal MucosaIntestinesMiceMuscarinic AgonistsNon-Neuronal Cholinergic SystemReceptors, MuscarinicReceptors, NicotinicAcetylcholineAnionsAtropineCholinergic AgonistsHexamethoniumMuscarinic AgonistsReceptors, MuscarinicReceptors, Nicotinicanion secretioncholinergicenteroidsmonolayersnicotinic

Identifiers

PMID32551856
PMCPMC7500216
OpenAlexW3036461251

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.