Evidence map›Paper›PMID 32551817›Full record

ArticleAmerican journal of respiratory and critical care medicine2020

Machine Learning Classifier Models Can Identify Acute Respiratory Distress Syndrome Phenotypes Using Readily Available Clinical Data.

Pratik Sinha, Matthew M Churpek, Carolyn S Calfee

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07511582 (Efficacy, Safety, and Tolerability of Methylprednisolone in Critically Ill Patients With the Hyperinflammatory Phenotype), which is not on this map. Cited by 126 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 2 pooled it
15.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07511582 phase2recruitingnot on this mapstarted 2026, after this paper: background citation

Efficacy, Safety, and Tolerability of Methylprednisolone in Critically Ill Patients With the Hyperinflammatory Phenotype: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase II Trial

TypeinterventionalSponsorBin DuRan2026 to 2028Enrolled150ConditionsSepsis, Acute Respiratory Distress SyndromeArmsMethylprednisolone (MP), Placebo
3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 2 syntheses or guidelines pooled it, 210 citations in OpenAlex.

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66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Pratik SinhaDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, and.
Matthew M ChurpekDepartment of Medicine, University of Wisconsin, Madison, Madison, Wisconsin.
Carolyn S CalfeeDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, and.
University of California, San Francisco · USUniversity of Wisconsin–Madison · US

Funding

Precision Medicine in the Acute Respiratory Distress SyndromeR35HL140026 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CALFEE, CAROLYN · 2018 to 2024
$6.8M
Comprehensive Anesthesia Research TrainingT32GM008440 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Judith Hellman · 1996 to 2026
$5.5M
Sepsis Early Prediction and Subphenotype Illumination Study (SEPSIS)R01GM123193 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI CHURPEK, MATTHEW MICHAEL · 2017 to 2021
$1.9M
NHLBI NIH HHS R35 HL140026NIGMS NIH HHS R01 GM123193NIGMS NIH HHS T32 GM008440
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Machine LearningAge FactorsAntigens, NeoplasmArea Under CurveBicarbonatesBilirubinBiomarkers, TumorBlood PressureCarbon DioxideCreatinineHumansInflammationIntercellular Adhesion Molecule-1Interleukin-6Interleukin-8Latent Class AnalysisAntigens, NeoplasmBicarbonatesBilirubinBiomarkers, TumorCarbon DioxideCreatinineCXCL8 protein, humanhuman epithelial antigen-125ICAM1 protein, humanIL6 protein, humanIntercellular Adhesion Molecule-1Interleukin-6Interleukin-8OxygenPlasminogen Activator Inhibitor 1Protein CReceptors, Tumor Necrosis Factor, Type ISERPINE1 protein, humanSerum AlbuminVasoconstrictor AgentsARDS phenotypesclassifier modelsmachine learning

Identifiers

PMID32551817
PMCPMC7528785
OpenAlexW3036339803

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.