Evidence map›Paper›PMID 32551539›Full record

ArticleACS chemical biology2020

A Toxic RNA Templates the Synthesis of Its Own Fluorogenic Inhibitor by Using a Bio-orthogonal Tetrazine Ligation in Cells and Tissues.

Alicia J Angelbello, Matthew D Disney

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Heterobifunctional small molecules to modulate RNA function.Trends in pharmacological sciences · 2024
    Review
  3. Targeting RNA structures with small molecules.Nature reviews. Drug discovery · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alicia J AngelbelloDepartment of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States.
Matthew D DisneyDepartment of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States.ORCID 0000-0001-8486-1796

Funding

Design of Precision Small Molecules Targeting RNA Repeating Transcripts to Manipulate and Study Disease BiologyR35NS116846 · NINDS · UNIVERSITY OF FLORIDA · PI Matthew D Disney · 2020 to 2026
$9.4M
Using a disease-affected cell to synthesize its own drugDP1NS096898 · NINDS · SCRIPPS FLORIDA · PI DISNEY, MATTHEW D · 2015 to 2019
$5.0M
Chemical approaches for precise recognition of a toxic RNA repeatF31NS110269 · NINDS · SCRIPPS FLORIDA · PI ANGELBELLO, ALICIA JEANNINE · 2018 to 2020
$64k
NINDS NIH HHS DP1 NS096898NINDS NIH HHS F31 NS110269NINDS NIH HHS R35 NS116846
6 · The paper itself

Abstract

Expanded RNA repeats cause more than 30 incurable diseases. One approach to mitigate their toxicity is by using small molecules that assemble into potent, oligomeric species upon binding to the disease-causing RNA in cells. Herein, we show that the expanded repeat [r(CUG)

Indexed as

AnimalsClick ChemistryFluoresceinsFluorescent DyesHeterocyclic Compounds, 1-RingHumansMiceMyotonic DystrophyMyotonin-Protein KinaseRNATandem Repeat SequencesTranscription, GeneticDMPK protein, humanDMPK protein, mouseFluoresceinsFluorescent DyesHeterocyclic Compounds, 1-RingMyotonin-Protein KinaseRNA

Identifiers

PMID32551539
PMCPMC7392402

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.