Evidence map›Paper›PMID 32551400›Full record

ArticleAmerican journal of ophthalmology case reports2020

On the axial location of Gunn's dots.

Daniel X Hammer, Zhuolin Liu, Jenna A Cava, Joseph Carroll, Osamah Saeedi

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05370287 (Adaptive Optics Retinal Imaging), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05370287 narecruitingnot on this map

Adaptive Optics Retinal Imaging

TypeinterventionalSponsorFood and Drug Administration (FDA)Ran2018 to 2028Enrolled150ConditionsGlaucoma, Primary Open AngleArmsoxygen inhalation, Adaptive optics imaging
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Adaptive Optics Imaging of Inherited Retinal Disease.Cold Spring Harbor perspectives in medicine · 2023
    Review
  3. Retinal alterations in patients with Lafora disease.American journal of ophthalmology case reports · 2021
    Article
  4. Review
  5. Unilateral benign yellow dot maculopathy.American journal of ophthalmology case reports · 2021
    Article
  6. Quantification of Retinal Ganglion Cell Morphology in Human Glaucomatous Eyes.Investigative ophthalmology & visual science · 2021
    Article
  7. Label-free adaptive optics imaging of human retinal macrophage distribution and dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Daniel X HammerDivision of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA.
Zhuolin LiuDivision of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA.
Jenna A CavaDepartment of Ophthalmology and Visual Sciences, Medical College of Wisconsin, 925 N. 87th Street, Milwaukee, WI, 53226, USA.
Joseph CarrollDepartment of Ophthalmology and Visual Sciences, Medical College of Wisconsin, 925 N. 87th Street, Milwaukee, WI, 53226, USA.
Osamah SaeediDepartment of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, 419 W. Redwood Street, Baltimore, MD, 21201, USA.

Funding

VISION RES LAB: HERPETIC KERATIC, CORE PIGMENT GENES, RETINITIS PIGMENTOSAC06RR016511 · NCRR · MEDICAL COLLEGE OF WISCONSIN · PI DUNN, MICHAEL J · 2002 to 2002
$1.4M
Role of Capillary Flow and Autoregulation in Primary Open Angle GlaucomaK23EY025014 · NEI · UNIVERSITY OF MARYLAND BALTIMORE · PI SAEEDI, OSAMAH JAWAID · 2015 to 2019
$1.0M
NCRR NIH HHS C06 RR016511NEI NIH HHS K23 EY025014
6 · The paper itself

Abstract

purposeTo determine the axial location of Gunn's dots in the retina.

methodsAdaptive optics scanning laser ophthalmoscopy (AOSLO) images and adaptive optics - optical coherence tomography (AO-OCT) volumes were collected from a region where Gunn's dots were found inferior to the optic disc from a subject determined by clinical examination to be a glaucoma suspect. AO-OCT volumes were also collected along the horizontal and vertical meridians from six healthy subjects and one glaucoma subject to identify and document other occurrences of Gunn's dots. AO-OCT volumes were registered in three-dimensions and averaged. Gunn's dots were segmented, and their volume, area, and diameter were measured.

resultsAll Gunn's dots imaged in this study from all subjects were confined to the inner limiting membrane, neither extending into the vitreous nor into the nerve fiber layer. The size of the dots was highly variable. The measured volume, area, and diameter (mean ± standard deviation) were 1119.9 ± 590.9 μm

conclusionsBased upon evidence from this study and others, Gunn's dots are not thought to be Müller cell end-feet or hyalocytes. We hypothesize that they are related to microglia, either as the by-product of their phagocytosis function, or are actual dead ameboid-shaped microglia who have fulfilled their scavenger role in retinal pathology. Further studies are needed in diseased eyes to determine if they have predictive value.

Indexed as

AO-OCTAOSLOGunn's dotsHyalocyteMicrogliaMüller cells

Identifiers

PMID32551400
PMCPMC7287238

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.