ArticleBone reports2020
Effect of size and location of simulated lytic lesions on the structural properties of human vertebral bodies, a micro-finite element study.
Article in Bone reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Effect of Posterior Element Removal in Thoracic and Lumbar Spine Segments With and Without Compromised Vertebral Microstructure Under Axial Compression.Annals of biomedical engineering · 2026Article
- Beyond SINS: A Critical Review of Biomechanical, Microstructural, and Radiomic Biomarkers for Predicting Fracture Risk in Spinal Metastases.Diagnostics (Basel, Switzerland) · 2026Review
- How to select a treatment method for patients with potentially unstable metastatic vertebrae (spinal instability neoplastic score 7-12): a systematic review.Asian spine journal · 2026Article
- Biomechanical effects of defect size and location on vertebral fracture.Journal of medical and biological engineering · 2025Article
- Computational Assessment of Fracture Risk in Vertebral Bodies With Simulated Defects: The Role of Baseline Strength and Tumor Size.International journal for numerical methods in biomedical engineering · 2025Article
- A finite element study of the effect of cross-link stabilisation in a lumbar spine tumour model.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2025Article
- Microstructure of the human metastatic vertebral body.Frontiers in endocrinology · 2024Article
- Computational homogenization of histological microstructures in human prostate tissue: Heterogeneity, anisotropy and tension-compression asymmetry.International journal for numerical methods in biomedical engineering · 2023Article
- Bone metastases do not affect the measurement uncertainties of a global digital volume correlation algorithm.Frontiers in bioengineering and biotechnology · 2023Article
- Osteolytic vs. Osteoblastic Metastatic Lesion: Computational Modeling of the Mechanical Behavior in the Human Vertebra after Screws Fixation Procedure.Journal of clinical medicine · 2022Article
- Finite Element Analysis of Osteoporotic and Osteoblastic Vertebrae and Its Association With the Proton Density Fat Fraction From Chemical Shift Encoding-Based Water-Fat MRI - A Preliminary Study.Frontiers in endocrinology · 2022Article
- Review
- Article
- Article
- Assessing the Mechanical Weakness of Vertebrae Affected by Primary Tumors: A Feasibility Study.Materials (Basel, Switzerland) · 2020Article
- Healing pattern classification for thoracolumbar burst fractures after posterior short-segment fixation.BMC musculoskeletal disorders · 2020Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Currently, the Spinal Instability Neoplastic Score system is used in clinics to evaluate the risk of fracture in patients with spinal metastases. This method, however, does not always provide a clear guideline due to the complexity in accounting for the effect of metastatic lesions on vertebral stability. The aim of this study was to use a validated micro Finite Element (microFE) modelling approach to analyse the effect of the size and location of lytic metastases on the mechanical properties of human vertebral bodies. Micro Computed Tomography based microFE models were generated with and without lytic lesions simulated as holes within a human vertebral body. Single and multiple lytic lesions were simulated with four different sizes and in five different locations. Bone was assumed homogenous, isotropic and linear elastic, and each vertebra was loaded in axial compression. It was observed that the size of lytic lesions was linearly related with the reduction in structural properties of the vertebral body (reduction of stiffness between 3% and 30% for lesion volume between 4% and 35%). The location of lytic lesions did not show a clear effect on predicted structural properties. Single or multiple lesions with the same volume provided similar results. Locally, there was a homogeneous distribution of axial principal strains among the models with and without lytic lesions. This study highlights the potential of microFE models to study the effect of lesions on the mechanical properties of the human vertebral body.
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