Evidence map›Paper›PMID 32551240›Full record

ArticleMethodsX2020

Typhim vi immunization assists to discriminate primary antibody responses in hematological malignancies.

J Ochoa-Grullón, C Orte, A Rodríguez de la Peña, K Guevara-Hoyer, G Cordero Torres, M Fernández-Arquero, I Serrano-García, M J Recio, R Pérez de Diego, S Sánchez-Ramón

Open access · goldAbstract read
In one paragraph

Article in MethodsX, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

J Ochoa-GrullónDepartment of Immunology, IML and IdSSC, Hospital Clínico San Carlos, Madrid, Spain.
C OrteDepartment of Immunology, IML and IdSSC, Hospital Clínico San Carlos, Madrid, Spain.
A Rodríguez de la PeñaDepartment of Immunology, IML and IdSSC, Hospital Clínico San Carlos, Madrid, Spain.
K Guevara-HoyerDepartment of Immunology, IML and IdSSC, Hospital Clínico San Carlos, Madrid, Spain.
G Cordero TorresDepartment of Immunology, IML and IdSSC, Hospital Clínico San Carlos, Madrid, Spain.
M Fernández-ArqueroDepartment of Immunology, IML and IdSSC, Hospital Clínico San Carlos, Madrid, Spain.
I Serrano-GarcíaDepartment of Epidemiology and Preventive Medicine, Hospital Clínico San Carlos, Madrid, Spain.
M J RecioImmunodeficiency Interdepartmental Group (GIID), Madrid, Spain.
R Pérez de DiegoImmunodeficiency Interdepartmental Group (GIID), Madrid, Spain.
S Sánchez-RamónDepartment of Immunology, IML and IdSSC, Hospital Clínico San Carlos, Madrid, Spain.
Hospital Clínico San Carlos · ESHospital La Paz Institute for Health Research · ESUniversidad Complutense de Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Assessment of specific antibody (Ab) production to polysaccharide antigens is clinically relevant, identifying patients at risk for infection by encapsulated bacteria and thus enabling a more rigorous selection of patients that can benefit of immunoglobulin replacement therapy. Classically, the gold-standard test is the measurement of antibody production to pure polysaccharide pneumococcal (PPV) immunization. Several factors, including introduction of conjugate vaccination schedule, serotyping analysis, high baseline Ab levels, have hindered the evaluation of polysaccharide antigens. This is even more difficult in secondary immunodeficiencies (SID), where patients can show secondary responses despite lack of primary antibody responses and present with recurrent or severe infections. Assessment of specific Ab production to pure S

Indexed as

Hematological MalignanciesPneumo 23Primary responsesROC curvesecondary responsesspecific polysaccharide Ab responseTyphim ViUnion index, cut-off valueYouden index

Identifiers

PMID32551240
PMCPMC7289764
OpenAlexW3029170155

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.