Evidence map›Paper›PMID 32551218›Full record

ArticleJournal of bone oncology2020

The local and circulating SOX9 as a potential biomarker for the diagnosis of primary bone cancer.

Ameinh Hosseini, Alireza Mirzaei, Vahid Salimi, Khodamorad Jamshidi, Pegah Babaheidarian, Soudabeh Fallah, Zahra Rampisheh, Narges Khademian, Zohreh Abdolvahabi, Mehrdad Bahrabadi and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of bone oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Ameinh HosseiniDepartment of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Alireza MirzaeiBone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran.
Vahid SalimiDepartment of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Khodamorad JamshidiBone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran.
Pegah BabaheidarianDepartment of Pathology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Soudabeh FallahDepartment of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Zahra RampishehPreventive Medicine and Public Health Research Center, Department of Community Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Narges KhademianDepartment of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Zohreh AbdolvahabiDepartment of Biochemistry and Genetics, Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Mehrdad BahrabadiBone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran.
Mostafa IbrahimiDepartment of Clinical Biochemistry, School of Medicine, Tarbiat Modares University, Tehran, Iran.
Fatemeh HosamiDepartment of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Masoumeh Tavakoli-YarakiDepartment of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Iran University of Medical Sciences · IRQazvin University of Medical Sciences · IRTarbiat Modares University · IRTehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe status of the local and circulating SOX9, a master regulator of the tumor fate, and its relevance to tumor types, severity, invasion feature, response to therapy, and chemotherapy treatment were surveyed in bone cancer in the current study.

methodsThe

resultsThe remarkable overexpression of

conclusionThe simultaneous overexpression of local and circulating SOX9 in bone cancer besides its positive correlation with tumor severity, malignancy, size, and chemotherapy may deserve receiving more attention in bone cancer diagnosis and therapy.

Indexed as

Benign bone tumorsBone cancerCPP, C - reactive protein testCSC, cancer stem cellCSC markerDAB, 3, 3′-diaminobenzidineESR, erythrocyte sedimentation rateFBS, fasting blood sugarFOXO1, Forkhead Box O1FOXO3, Forkhead Box O3GCT, giant cell tumorHB, memoglobinLDL, low-density lipoproteinMalignant bone tumorsMSC, multipotent stem cellsOCT, optimal cutting temperaturePBMC, peripheral blood mononuclear cellPBS, phosphate-buffered salinePMSF, phenylmethylsulfonyl fluoridePVDF, polyvinylidene difluorideRBC, red blood cellSEM, standard error meanSOX9SOX9, SRY-Box Transcription Factor 9WBC, white blood cells

Identifiers

PMID32551218
PMCPMC7292907
OpenAlexW3031366616

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.