ArticleAcute medicine & surgery
Clinical characteristics, prognostic factors, and outcomes of heat-related illness (Heatstroke Study 2017-2018).
Article in Acute medicine & surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 55 citations in OpenAlex.
- Nationwide analysis of cases of emergency transport due to heatstroke in Japan from 2010 to 2024.Scientific reports · 2026Article
- Early seizures and heterogeneity of physiologic recovery in heat-related illness: a nationwide registry study.Critical care (London, England) · 2026Article
- Disseminated intravascular coagulation as a prognostic factor in heatstroke: a retrospective cohort study based on Japanese insurance claims.Frontiers in medicine · 2026Article
- Characteristics of pediatric patients with heat-related illness transferred to emergency departments: a descriptive analysis from Japan.Clinical and experimental emergency medicine · 2025Article
- In-hospital mortality of heat-related disease associated with wet bulb globe temperature: a Japanese nationwide inpatient data analysis.International journal of biometeorology · 2025Article
- The feasibility of point-of-care testing for initial urinary liver fatty acid-binding protein to estimate severity in severe heatstroke.Scientific reports · 2025Article
- Diagnosis and Management of Heat-related Illness: Clinical and Molecular Perspectives.Juntendo medical journal · 2025Review
- Leukocyte mRNA sequencing reveals unfolded protein response activation in severe heat stroke in Japan.Frontiers in cell and developmental biology · 2025Article
- Article
- Independent Predictors of Heat-Related Illness-Induced Acute Respiratory Failure: A Multicenter Cross-sectional Study.Archives of academic emergency medicine · 2025Article
- The pathogenesis and therapeutic strategies of heat stroke-induced endothelial injury.Frontiers in cell and developmental biology · 2025Review
- Developing a molecular diagnostic model for heatstroke-induced coagulopathy: a proteomics and metabolomics approach.Frontiers in molecular biosciences · 2025Article
- A newly proposed heatstroke-induced coagulopathy score in patients with heat illness: A multicenter retrospective study in China.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2024Article
- Development and validation of a risk prediction model for multiple organ dysfunction syndrome secondary to severe heat stroke based on immediate assessment indicators on ICU admission.Frontiers in medicine · 2024Article
- Mechanism of Acute Kidney Injury in Mild to Moderate Heat-related Illness.Juntendo Iji zasshi = Juntendo medical journal · 2024Article
- Development and validation of a prognostic model of survival for classic heatstroke patients: a multicenter study.Scientific reports · 2023Article
- Holistic view of heat acclimation alleviated intestinal lesion in mice with heat stroke based on microbiome-metabolomics analysis.Microbial biotechnology · 2023Article
- Glasgow Coma Scale as an Indicator of Patient Prognosis: A Retrospective Study of 257 Patients with Heatstroke from 3 Medical Centers in Guangdong, China.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Inflammation, coagulation, and cellular injury in heat-induced shock.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Review
- Early biomarkers for kidney injury in heat-related illness patients: a prospective observational study at Japanese Self-Defense Force Fuji Hospital.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023Observational
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Authors and funding
17 authors at 15 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimHeat-related illness is common, but its epidemiology and pathological mechanism remain unclear. The aim of this study was to report current clinical characteristics, prognostic factors, and outcomes of heat-related illness in Japan.
methodsWe undertook a prospective multicenter observational study in Japan. Only hospitalized patients with heat-related illness were enrolled from 1 July to 30 September 2017 and 1 July to 30 September 2018.
resultsA total of 763 patients were enrolled in the study. Median age was 68 years (interquartile range, 49-82 years) and median body temperature on admission was 38.2°C (interquartile range, 36.8-39.8°C). Non-exertional cause was 56.9% and exertional cause was 40.0%. The hospital mortality was 4.6%. The median Japanese Association for Acute Medicine disseminated intravascular coagulation (JAAM DIC), Sequential Organ Failure Assessment (SOFA), and Acute Physiology and Chronic Health Evaluation II (APACHE II) scores on admission were 1 (0-2), 4 (2-6), and 13 (8-22), respectively. To predict hospital mortality, areas under the receiver operating characteristic curves were 0.776 (JAAM DIC score), 0.825 (SOFA), and 0.878 (APACHE II). There were 632 cases defined as heatstroke by JAAM heat-related illness criteria, 73 cases diagnosed as having DIC. A total of 16.6% patients had poor neurological outcome (modified Rankin Scale ≥ 4) at hospital discharge. In the multivariate analysis, Glasgow Coma Scale and platelets were independent predictors of mortality. Type of heatstroke, Glasgow Coma Scale, and platelets were independent predictors of poor neurological outcome. Body temperature was not associated with mortality or poor neurological outcome.
conclusionsIn this study, hospital mortality of heat-related illness was <5%, one-sixth of the patients had poor neurological outcome. The APACHE II, SOFA, and JAAM DIC scores predicted hospital mortality. Body temperature was not associated with mortality or poor neurological outcome.
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