ArticleComputational and structural biotechnology journal2020
Investigating metabolic interactions in a microbial co-culture through integrated modelling and experiments.
Article in Computational and structural biotechnology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
- Plant growth-promoting Pseudomonas strains modulate potato tuberization signalling and development.Journal of experimental botany · 2026Article
- Evaluating Metabolic Support in Pairwise Microbial Communities Using MetQuest.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Pretreatment of lignocellulosic biomass and biogas production from a microbial consortium recovered from soil litter and termite gut.World journal of microbiology & biotechnology · 2025Article
- Gas-Phase Integration of Trophically Distinct Microbial Cultures for Net-Reduced COMicrobial biotechnology · 2025Article
- Microbial Interactions in Food Fermentation: Interactions, Analysis Strategies, and Quality Enhancement.Foods (Basel, Switzerland) · 2025Review
- Genome-Scale Community Model-Guided Development of Bacterial Coculture for Lignocellulose Bioconversion.Biotechnology and bioengineering · 2025Article
- Article
- A systematic approach to determine the outcome of the competition between two microbial species in bioreactor cocultures.Antonie van Leeuwenhoek · 2024Article
- Co-Culture of Gut Bacteria and Metabolite Extraction Using Fast Vacuum Filtration and Centrifugation.Methods and protocols · 2024Article
- Endophytic fungi: A future prospect for breast cancer therapeutics and drug development.Heliyon · 2024Review
- GEM-based computational modeling for exploring metabolic interactions in a microbial community.PLoS computational biology · 2024Article
- Modeling Microbial Community Networks: Methods and Tools for Studying Microbial Interactions.Microbial ecology · 2024Review
- Top-down and bottom-up microbiome engineering approaches to enable biomanufacturing from waste biomass.Journal of industrial microbiology & biotechnology · 2024Review
- Strategies for tailoring functional microbial synthetic communities.The ISME journal · 2024Review
- Investigating the Stirred Tank Bioreactor Co-Cultures of the Secondary Metabolite ProducersBiomolecules · 2023Article
- Uncovering Predictive Factors and Interventions for Restoring Microecological Diversity after Antibiotic Disturbance.Nutrients · 2023Article
- Metagenome-based metabolic modelling predicts unique microbial interactions in deep-sea hydrothermal plume microbiomes.ISME communications · 2023Article
- Metabolic modeling of the International Space Station microbiome reveals key microbial interactions.Microbiome · 2022Article
- Article
- Endophytic Fungi: Key Insights, Emerging Prospects, and Challenges in Natural Product Drug Discovery.Microorganisms · 2022Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbial co-cultures have been used in several biotechnological applications. Within these co-cultures, the microorganisms tend to interact with each other and perform complex actions. Investigating metabolic interactions in microbial co-cultures is crucial in designing microbial consortia. Here, we present a pipeline integrating modelling and experimental approaches to understand metabolic interactions between organisms in a community. We define a new index named "Metabolic Support Index (MSI)", which quantifies the benefits derived by each organism in the presence of the other when grown as a co-culture. We computed MSI for several experimentally demonstrated co-cultures and showed that MSI, as a metric, accurately identifies the organism that derives the maximum benefit. We also computed MSI for a commonly used yeast co-culture consisting of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.