ArticleACS medicinal chemistry letters2020
ONO-8430506: A Novel Autotaxin Inhibitor That Enhances the Antitumor Effect of Paclitaxel in a Breast Cancer Model.
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Article in ACS medicinal chemistry letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Decoding lysophosphatidic acid signaling in physiology and disease: mapping the multimodal and multinodal signaling networks.Signal transduction and targeted therapy · 2025Review
- Inhibition of autotaxin activity with IOA-289 decreases fibrosis in mouse E0771 breast tumors.International journal of cancer · 2025Article
- Structure-Based Discovery of MolPort-137: A Novel Autotaxin Inhibitor That Improves Paclitaxel Efficacy.International journal of molecular sciences · 2025Article
- Novel Autotaxin Inhibitor ATX-1d Significantly Enhances Potency of Paclitaxel-An In Silico and In Vitro Study.Molecules (Basel, Switzerland) · 2024Article
- The Emerging Role of LPA as an Oncometabolite.Cells · 2024Review
- Autotaxin and Lysophosphatidate Signaling: Prime Targets for Mitigating Therapy Resistance in Breast Cancer.World journal of oncology · 2024Review
- A comprehensive review of discovery and development of drugs discovered from 2020-2022.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Review
- Dual role of autotaxin as novel biomarker and therapeutic target in pancreatic neuroendocrine neoplasms.Cancer science · 2023Article
- Autotaxin production in the human breast cancer tumor microenvironment mitigates tumor progression in early breast cancers.American journal of cancer research · 2023Article
- Role of autotaxin in systemic lupus erythematosus.Frontiers in medicine · 2023Review
- Designing Dual Inhibitors of Autotaxin-LPAR GPCR Axis.Molecules (Basel, Switzerland) · 2022Review
- Roles of Autotaxin/Autotaxin-Lysophosphatidic Acid Axis in the Initiation and Progression of Liver Cancer.Frontiers in oncology · 2022Review
- Design and Development of Autotaxin Inhibitors.Pharmaceuticals (Basel, Switzerland) · 2021Review
- An ATX-LPAiScience · 2021Article
- Discovery of Potent Selective Nonzinc Binding Autotaxin Inhibitor BIO-32546.ACS medicinal chemistry letters · 2021Article
- Inhibition of autotaxin activity ameliorates neuropathic pain derived from lumbar spinal canal stenosis.Scientific reports · 2021Article
- Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies.Signal transduction and targeted therapy · 2021Review
- Structure-Based Discovery of Novel Chemical Classes of Autotaxin Inhibitors.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
21 authors at 1 institution in 1 country.
Yuzo IwakiMedicinal Chemistry Research Laboratories,Chemical Process Research Laboratories,Exploratory Research Laboratories,Pharmaceutical Technology Laboratories, and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.
Akira OhhataMedicinal Chemistry Research Laboratories,Chemical Process Research Laboratories,Exploratory Research Laboratories,Pharmaceutical Technology Laboratories, and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.
Shingo NakataniMedicinal Chemistry Research Laboratories,Chemical Process Research Laboratories,Exploratory Research Laboratories,Pharmaceutical Technology Laboratories, and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.
Katsuya HisaichiMedicinal Chemistry Research Laboratories,Chemical Process Research Laboratories,Exploratory Research Laboratories,Pharmaceutical Technology Laboratories, and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.
Yasuyuki OkabeMedicinal Chemistry Research Laboratories,Chemical Process Research Laboratories,Exploratory Research Laboratories,Pharmaceutical Technology Laboratories, and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.
Atsushi HiramatsuMedicinal Chemistry Research Laboratories,Chemical Process Research Laboratories,Exploratory Research Laboratories,Pharmaceutical Technology Laboratories, and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.
Toshihide WatanabeMedicinal Chemistry Research Laboratories,Chemical Process Research Laboratories,Exploratory Research Laboratories,Pharmaceutical Technology Laboratories, and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.
Shingo YamamotoMedicinal Chemistry Research Laboratories,Chemical Process Research Laboratories,Exploratory Research Laboratories,Pharmaceutical Technology Laboratories, and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.
Taihei NishiyamaMedicinal Chemistry Research Laboratories,Chemical Process Research Laboratories,Exploratory Research Laboratories,Pharmaceutical Technology Laboratories, and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.
Juta KobayashiMedicinal Chemistry Research Laboratories,Chemical Process Research Laboratories,Exploratory Research Laboratories,Pharmaceutical Technology Laboratories, and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.
Yasuo HirookaMedicinal Chemistry Research Laboratories,Chemical Process Research Laboratories,Exploratory Research Laboratories,Pharmaceutical Technology Laboratories, and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.
Hideki MoriguchiMedicinal Chemistry Research Laboratories,Chemical Process Research Laboratories,Exploratory Research Laboratories,Pharmaceutical Technology Laboratories, and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.
Tatsuo MaedaMedicinal Chemistry Research Laboratories,Chemical Process Research Laboratories,Exploratory Research Laboratories,Pharmaceutical Technology Laboratories, and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.
Makoto KatohMedicinal Chemistry Research Laboratories,Chemical Process Research Laboratories,Exploratory Research Laboratories,Pharmaceutical Technology Laboratories, and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.
Yuka KomichiMedicinal Chemistry Research Laboratories,Chemical Process Research Laboratories,Exploratory Research Laboratories,Pharmaceutical Technology Laboratories, and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.
Hiroto OtaMedicinal Chemistry Research Laboratories,Chemical Process Research Laboratories,Exploratory Research Laboratories,Pharmaceutical Technology Laboratories, and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.
Naoya MatsumuraMedicinal Chemistry Research Laboratories,Chemical Process Research Laboratories,Exploratory Research Laboratories,Pharmaceutical Technology Laboratories, and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.
Masahiro OkadaMedicinal Chemistry Research Laboratories,Chemical Process Research Laboratories,Exploratory Research Laboratories,Pharmaceutical Technology Laboratories, and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.
Tetsuya SugiyamaMedicinal Chemistry Research Laboratories,Chemical Process Research Laboratories,Exploratory Research Laboratories,Pharmaceutical Technology Laboratories, and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.
Hiroshi SagaMedicinal Chemistry Research Laboratories,Chemical Process Research Laboratories,Exploratory Research Laboratories,Pharmaceutical Technology Laboratories, and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.
Akira ImagawaMedicinal Chemistry Research Laboratories,Chemical Process Research Laboratories,Exploratory Research Laboratories,Pharmaceutical Technology Laboratories, and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.
Ono Pharmaceutical (Japan) · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lysophosphatidic acid (LPA) is a bioactive lipid mediator that elicits a number of biological functions, including smooth muscle contraction, cell motility, proliferation, and morphological change. LPA is endogenously produced by autotaxin (ATX) from extracellular lysophosphatidylcholine (LPC) in plasma. Herein, we report our medicinal chemistry effort to identify a novel and highly potent ATX inhibitor, ONO-8430506 (
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