ArticleACS medicinal chemistry letters2020
Characterization of Specific
Abstract read
In one paragraph
Article in ACS medicinal chemistry letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- NAA50-mediated SLU7 stabilization promotes cisplatin resistance in bladder cancer via regulating MAP3K3 mRNA nuclear export and p38 MAPK activation.Cellular oncology (Dordrecht, Netherlands) · 2026Article
- Hierarchical small molecule inhibition of MYST acetyltransferases.Nature communications · 2026Article
- Above-Filter Digestion Proteomics Reveals Drug Targets and Localizes Ligand Binding Site.Journal of proteome research · 2026Article
- Solid-phase DNA-encoded library synthesis: a master builder's instructions.Nature protocols · 2026Review
- Hierarchical small molecule inhibition of MYST acetyltransferases.bioRxiv : the preprint server for biology · 2025Article
- Small-molecule discovery through DNA-encoded libraries.Nature reviews. Drug discovery · 2023Review
- Chemoproteomics Yields a Selective Molecular Host for Acetyl-CoA.Journal of the American Chemical Society · 2023Article
- An evolutionary history of the CoA-binding protein Nat/Ivy.Protein science : a publication of the Protein Society · 2022Review
- Expanding the DNA-encoded library toolbox: identifying small molecules targeting RNA.Nucleic acids research · 2022Article
- Opportunities for Expanding Encoded Chemical Diversification and Improving Hit Enrichment in mRNA-Displayed Peptide Libraries.Chembiochem : a European journal of chemical biology · 2022Review
- Machine Learning on DNA-Encoded Library Count Data Using an Uncertainty-Aware Probabilistic Loss Function.Journal of chemical information and modeling · 2022Review
- Highly efficient on-DNA amide couplings promoted by micelle forming surfactants for the synthesis of DNA encoded libraries.Chemical science · 2021Article
- DNA-Encoded Chemistry: Drug Discovery from a Few Good Reactions.Chemical reviews · 2021Review
- Harnessing Ionic Selectivity in Acetyltransferase Chemoproteomic Probes.ACS chemical biology · 2021Article
- N-Terminal Acetyltransferases Are Cancer-Essential Genes Prevalently Upregulated in Tumours.Cancers · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors.
Pei-Pei KungWorldwide Research and Development, Pfizer Inc., 10770 Science Center Drive, San Diego, California 92121, United States.
Patrick BinghamWorldwide Research and Development, Pfizer Inc., 10770 Science Center Drive, San Diego, California 92121, United States.
Benjamin J BurkeWorldwide Research and Development, Pfizer Inc., 10770 Science Center Drive, San Diego, California 92121, United States.
Qiuxia ChenHitGen Inc., Building 6, No.8, Huigu first East Road, Tianfu International Bio-Town, Shuangliu District, Chengdu, Sichuan 610200, P.R. China.
Xuemin ChengHitGen Inc., Building 6, No.8, Huigu first East Road, Tianfu International Bio-Town, Shuangliu District, Chengdu, Sichuan 610200, P.R. China.
Ya-Li DengWorldwide Research and Development, Pfizer Inc., 10770 Science Center Drive, San Diego, California 92121, United States.
Dengfeng DouHitGen Inc., Building 6, No.8, Huigu first East Road, Tianfu International Bio-Town, Shuangliu District, Chengdu, Sichuan 610200, P.R. China.
Junli FengWorldwide Research and Development, Pfizer Inc., 10770 Science Center Drive, San Diego, California 92121, United States.
Gary M GallegoWorldwide Research and Development, Pfizer Inc., 10770 Science Center Drive, San Diego, California 92121, United States.
Michael R GehringWorldwide Research and Development, Pfizer Inc., 10770 Science Center Drive, San Diego, California 92121, United States.
Stephan K GrantWorldwide Research and Development, Pfizer Inc., 10770 Science Center Drive, San Diego, California 92121, United States.
Samantha GreasleyWorldwide Research and Development, Pfizer Inc., 10770 Science Center Drive, San Diego, California 92121, United States.
Anthony R HarrisWorldwide Research and Development, Pfizer Inc., 10770 Science Center Drive, San Diego, California 92121, United States.
Karen A MaegleyWorldwide Research and Development, Pfizer Inc., 10770 Science Center Drive, San Diego, California 92121, United States.
Jordan MeierChemical Biology Laboratory, National Cancer Institute, Frederick, Maryland 21702, United States.
Xiaoyun MengHitGen Inc., Building 6, No.8, Huigu first East Road, Tianfu International Bio-Town, Shuangliu District, Chengdu, Sichuan 610200, P.R. China.
Jose L MontanoChemical Biology Laboratory, National Cancer Institute, Frederick, Maryland 21702, United States.
Barry A MorganHitGen Pharmaceuticals Inc., PO Box 88240, Houston, Texas 77288, United States.
Brigitte S NaughtonWorldwide Research and Development, Pfizer Inc., 10770 Science Center Drive, San Diego, California 92121, United States.
Prakash B PaldeWorldwide Research and Development, Pfizer Inc., 10770 Science Center Drive, San Diego, California 92121, United States.
Thomas A PaulWorldwide Research and Development, Pfizer Inc., 10770 Science Center Drive, San Diego, California 92121, United States.
Paul RichardsonWorldwide Research and Development, Pfizer Inc., 10770 Science Center Drive, San Diego, California 92121, United States.
Sylvie SakataWorldwide Research and Development, Pfizer Inc., 10770 Science Center Drive, San Diego, California 92121, United States.
Alex ShaginianHitGen Inc., Building 6, No.8, Huigu first East Road, Tianfu International Bio-Town, Shuangliu District, Chengdu, Sichuan 610200, P.R. China.
William K SonnenburgHitGen Inc., Building 6, No.8, Huigu first East Road, Tianfu International Bio-Town, Shuangliu District, Chengdu, Sichuan 610200, P.R. China.
Chakrapani SubramanyamWorldwide Research and Development, Pfizer Inc., 10770 Science Center Drive, San Diego, California 92121, United States.
Sergei TimofeevskiWorldwide Research and Development, Pfizer Inc., 10770 Science Center Drive, San Diego, California 92121, United States.
Jinqiao WanHitGen Inc., Building 6, No.8, Huigu first East Road, Tianfu International Bio-Town, Shuangliu District, Chengdu, Sichuan 610200, P.R. China.
Wen YanWorldwide Research and Development, Pfizer Inc., 10770 Science Center Drive, San Diego, California 92121, United States.
Albert E StewartWorldwide Research and Development, Pfizer Inc., 10770 Science Center Drive, San Diego, California 92121, United States.
Funding
Targeting Cancer Through Modifications and MetabolismZIABC011488 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MEIER, JORDAN L · 2013 to 2025
$21.3MAbstract
Two novel compounds were identified as Naa50 binders/inhibitors using DNA-encoded technology screening. Biophysical and biochemical data as well as cocrystal structures were obtained for both compounds (
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What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.