Evidence map›Paper›PMID 32550884›Full record

ArticleExperimental and therapeutic medicine2020

Effects of icariin on cell injury and glucocorticoid resistance in BEAS-2B cells exposed to cigarette smoke extract.

Lingli Hu, Feng Liu, Lulu Li, Li Zhang, Chen Yan, Qiuping Li, Jian Qiu, Jingcheng Dong, Jing Sun, Hongying Zhang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  5. A comprehensive narrative review ofJournal of pharmaceutical analysis · 2026
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  12. Polyphenols, flavonoids and inflammasomes: the role of cigarette smoke in COPD.European respiratory review : an official journal of the European Respiratory Society · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Lingli HuDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
Feng LiuDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
Lulu LiDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
Li ZhangDepartment of Rehabilitation, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
Chen YanDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
Qiuping LiDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
Jian QiuDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
Jingcheng DongDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
Jing SunDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
Hongying ZhangDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
Fudan University · CNHuashan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glucocorticoids (GCs) exert a therapeutic effect in numerous chronic inflammatory diseases. However, chronic obstructive pulmonary disease (COPD) tends to be GC-resistant. Icariin, a major component of flavonoids isolated from Epimedium brevicornum Maxim (Berberidaceae), significantly relieves symptoms in patients with COPD. However, the mechanism of action remains unclear and further investigation is required to establish whether it may serve as an alternative or complementary therapy for COPD. The aim of the present study was to determine the effects of icariin in human bronchial epithelial cells exposed to cigarette smoke extract (CSE) and to determine whether icariin reverses GC resistance. The results revealed that icariin significantly increased the proliferation of CSE-exposed cells. Furthermore, icariin significantly increased protein expression of the anti-inflammatory factor interleukin (IL)-10 and significantly decreased protein expression of the pro-inflammatory factors IL-8 and tumor necrosis factor α. Icariin also attenuated the expression of the cellular matrix remodelling biomarkers matrix metallopeptidase 9 and tissue inhibitor of metalloproteinase 1, and decreased the production of reactive oxygen species (ROS). In addition, icariin regulated the expression of GC resistance-related factors, such as GC receptors, histone deacetylase 2, nuclear factor erythroid-2-related factor 2 and nuclear factor κ B. The results obtained in the present study suggested that icariin may decrease CSE-induced inflammation, airway remodelling and ROS production by mitigating GC resistance. In conclusion, icariin may potentially be used in combination with GCs to increase therapeutic efficacy and reduce GC resistance in COPD.

Indexed as

airway remodellingchronic obstructive pulmonary diseasecigarette smoke extractglucocorticoid resistanceicariininflammationreactive oxygen species

Identifiers

PMID32550884
PMCPMC7296294
OpenAlexW3022274838

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.