ArticleObstetrics & gynecology science2020
Cervicovaginal fluid cytokines as predictive markers of preterm birth in symptomatic women.
Article in Obstetrics & gynecology science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 55 citations in OpenAlex.
- Exploring the Potential of Wharton's Jelly-Derived Mesenchymal Stem Cells as a Therapeutic Approach for Preterm Premature Rupture of Membranes.International journal of stem cells · 2026Article
- The neutrophil-to-lymphocyte ratio: a marker for microbial invasion of the amniotic cavity in preterm prelabor rupture of membranes.Obstetrics & gynecology science · 2026Article
- Artificial intelligence in preterm birth prediction: a narrative review of current approaches and clinical applicability.Obstetrics & gynecology science · 2026Review
- Predictive modeling for cervical cancer: existing AI approaches and the emerging role of vaginal microbiome.Frontiers in network physiology · 2026Article
- Arachidonic Acid-Induced Contraction of Smooth Muscle Is Mediated by MLC Phosphorylation in Preterm Birth.Journal of pregnancy · 2026Article
- Vaginal microbiome and its implications in preterm birth.Obstetrics & gynecology science · 2025Review
- Feasibility of Multiplex Cytokine Profiling in Preterm Labor: Towards Biomarker Discovery.Biology · 2025Article
- Human Milk Oligosaccharides Mediate the Host-Microbe Interface in a Model Vaginal Community.ACS infectious diseases · 2025Article
- Observational
- Identification of Short-Chain Fatty Acids for Predicting Preterm Birth in Cervicovaginal Fluid Using Mass Spectrometry.International journal of molecular sciences · 2024Article
- Dysbiotic Vaginal Microbiota Induces Preterm Birth Cascade via Pathogenic Molecules in the Vagina.Metabolites · 2024Article
- Association of recurrent implantation failure and recurrent pregnancy loss with peripheral blood natural killer cells and interferon-gamma level.Obstetrics & gynecology science · 2024Article
- The Utility of Human Milk Oligosaccharides against Group BACS central science · 2023Article
- How to screen the cervix and reduce the risk of spontaneous preterm birth in asymptomatic women without a prior preterm birth.Obstetrics & gynecology science · 2023Article
- Potential biomarkers to predict return to fertility after discontinuation of female contraceptives-looking to the future.Frontiers in reproductive health · 2023Review
- A genome-wide and candidate gene association study of preterm birth in Korean pregnant women.PloS one · 2023Article
- Streptococcus agalactiae cadD alleviates metal stress and promotes intracellular survival in macrophages and ascending infection during pregnancy.Nature communications · 2022Article
- Ureaplasma and Prevotella colonization with Lactobacillus abundance during pregnancy facilitates term birth.Scientific reports · 2022Article
- Effects of vaginal microecology and immunity on the pregnancy outcome of cervical cerclage.BMC women's health · 2022Article
- Efficacy of atosiban combined with ritodrine on spontaneous threatened preterm birth and its effect on PAF and fFN levels.American journal of translational research · 2022Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveHere, we investigated whether cytokines in the cervicovaginal fluid (CVF) can be predictive markers of preterm birth (PTB).
methodsA multi-center prospective cohort study was conducted on 59 singleton pregnant women hospitalized for preterm labor (PTL) and/or preterm premature rupture of membranes (pPROM) between 22 weeks and 36 weeks 6 days of gestation from 2014 to 2015. The levels of 13 inflammatory cytokines (macrophage inflammatory protein [MIP]-1α, MIP-1β, tumor necrosis factor [TNF]-α, interleukin [IL]-1β, IL-6, IL-8, IL-17α, granulocyte colony stimulating factor [G-CSF], IL-7, IL-4, IL-5, IL-10, and IL-13) were measured using a multiplex bead-based immunoassay and that of fetal fibronectin (fFN) was measured using enzyme-linked immunosorbent assay (ELISA). Statistical analyses were performed using Student's t-test, Mann-Whitney U test, Pearson's correlation, and receiver operating characteristic (ROC) curve analysis in SPSS version 20.0.
resultsAmong the 13 cytokines assessed, the levels of 3 cytokines (MIP-1α, IL-6, and IL-7) were negatively correlated with gestational age at delivery (P=0.028, P=0.002, and P=0.018, respectively). Sensitivities of MIP-1α, IL-6, and IL-17α were 70%, 80%, and 75%, respectively, and their specificities were 57%, 65%, and 69%, respectively. The sensitivity and specificity of fFN were 33% and 95%, respectively.
conclusionIn symptomatic women diagnosed with PTL and/or pPROM, cytokines from cervicovaginal fluid, especially IL-6 and IL-17α, could be better predictive markers of PTB than fFN.
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