Evidence map›Paper›PMID 32550545›Full record

ArticleGene: X2019

Analysis of RAMP3 gene polymorphism with body composition and bone density in young and elderly women.

Jai Prakash, Maria Herlin, Jitender Kumar, Gaurav Garg, Kristina E Akesson, Peter S Grabowski, Tim M Skerry, Gareth O Richards, Fiona E A McGuigan

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gene: X, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Dawn of a New RAMPage.Trends in pharmacological sciences · 2020
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Jai PrakashLund University, Dept. of Clinical Sciences Malmö, Clinical and Molecular Osteoporosis Research Unit, Sweden.
Maria HerlinLund University, Dept. of Clinical Sciences Malmö, Clinical and Molecular Osteoporosis Research Unit, Sweden.
Jitender KumarAmity Institute of Biotechnology, Amity University Uttar Pradesh, Noida, India.
Gaurav GargGenomics Division, LCGC Life sciences LLP, New Delhi, India.
Kristina E AkessonLund University, Dept. of Clinical Sciences Malmö, Clinical and Molecular Osteoporosis Research Unit, Sweden.
Peter S GrabowskiHuman Nutrition Unit, Dept. of Oncology and Metabolism, Sheffield University, UK.
Tim M SkerryAcademic Unit of Bone Biology, Dept. of Oncology and Metabolism, Sheffield University, UK.
Gareth O RichardsAcademic Unit of Bone Biology, Dept. of Oncology and Metabolism, Sheffield University, UK.
Fiona E A McGuiganLund University, Dept. of Clinical Sciences Malmö, Clinical and Molecular Osteoporosis Research Unit, Sweden.
Lund University · SEUniversity of Sheffield · GBAmity University · INSkåne University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimThe Receptor Activity Modifying Proteins (RAMPs) are a group of accessory proteins, of which there are three in humans, that interact with a number of G-protein coupled receptors (GPCR) and play various roles in regulation of endocrine signaling. Studies in RAMP3 knockout (KO) mice reveal an age related phenotype with altered metabolic regulation and high bone mass. To translate these findings into a clinically relevant perspective, we investigated the association between

methodsFive single nucleotide polymorphisms (SNP) in the vicinity of the RAMP3 gene were genotyped in the PEAK-25 cohort (n = 1061; 25 years) and OPRA (n = 1044; 75 years). Bone mineral density (BMD), fat mass and lean mass (total body; regional) were measured by DXA at baseline, 5 and 10 year follow-up.

resultsBMD did not differ with

conclusionVariation in

Indexed as

AM1R, Adrenomedullin-1 ReceptorAM2R, Adrenomedullin-2 ReceptorAMY3, Amylin Receptor ComplexBMDBMD, Bone Mineral DensityCGRP, Calcitonin Gene-Related PeptideCLR, Calcitonin Like-ReceptorFatFM, Fat MassFN, Femoral NeckFractureGPCR, G-Protein Coupled ReceptorKO, Knock-outLM, Lean MassLS, Lumbar SpineOPRA, Osteoporosis Prospective Risk AssessmentRAMP3RAMP3, Receptor Activity Modifying Protein 3SNPSNP, Single Nucleotide PolymorphismTB, Total Body

Identifiers

PMID32550545
PMCPMC7286079
OpenAlexW2914593438

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.