Identification of the evolutionarily conserved nuclear envelope proteins Lem2 and MicLem2 in

Masaaki Iwamoto, Yasuhiro Fukuda, Hiroko Osakada, Chie Mori, Yasushi Hiraoka, Tokuko Haraguchi

Open access · hybridAbstract read

In one paragraph

Article in Gene: X, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

0.3field-weighted citation impact, top 45% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

The Sky's the LEMit: New insights into nuclear structure regulation of transcription factor activity.Current opinion in cell biology · 2021
Review
Nuclear Envelope Proteins Modulating the Heterochromatin Formation and Functions in Fission Yeast.Cells · 2020
Review

4 · The record

Corrections and comments

Reprinted as
Identification of the evolutionarily conserved nuclear envelope proteins Lem2 and MicLem2 in Tetrahymena thermophila.2019

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Masaaki IwamotoAdvanced ICT Research Institute Kobe, National Institute of Information and Communications Technology, Kobe 651-2492, Japan.

Yasuhiro FukudaGraduate School of Agricultural Science, Tohoku University, Osaki, 989-6711, Japan.

Hiroko OsakadaAdvanced ICT Research Institute Kobe, National Institute of Information and Communications Technology, Kobe 651-2492, Japan.

Chie MoriAdvanced ICT Research Institute Kobe, National Institute of Information and Communications Technology, Kobe 651-2492, Japan.

Yasushi HiraokaAdvanced ICT Research Institute Kobe, National Institute of Information and Communications Technology, Kobe 651-2492, Japan.

Tokuko HaraguchiAdvanced ICT Research Institute Kobe, National Institute of Information and Communications Technology, Kobe 651-2492, Japan.

National Institute of Information and Communications Technology · JPTohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lem2 family proteins, i.e. the LAP2-Emerin-MAN1 (LEM) domain-containing nuclear envelope proteins, are well-conserved from yeasts to humans, both of which belong to the Opisthokonta supergroup. However, whether their homologs are present in other eukaryotic phylogenies remains unclear. In this study, we identified two Lem2 homolog proteins, which we named as Lem2 and MicLem2, in a ciliate

Indexed as

BAF, barrier-to-autointegration factorDAPI, 4′,6‑diamidino‑2‑phenylindoleDDW, double distilled waterEDTA, ethylenediaminetetraacetic acidER, endoplasmic reticulumGA, glutaraldehydeHeH domainHeH, helix-extension-helixLAP2, lamina associated polypeptide 2LEM domainLEM, LAP2-Emerin-MAN1MAC, macronucleusMan1Man1-Src1p-C-terminal domainMIC, micronucleusMSC domainMSC, Man1-Src1p-C-terminalNE, nuclear envelopeNLS, nuclear localization signalNPC, nuclear pore complexNuclear dimorphismNuclear envelopeONM and INM, outer and inner nuclear membranesPB, phosphate bufferPBS, phosphate buffered salineProtistRRM, RNA recognition motifTM, transmembrane

Identifiers

PMID32550543

DOI10.1016/j.gene.2019.100006

PMCPMC7285967

OpenAlexW2912506703

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.