Evidence map›Paper›PMID 32550542›Full record

ArticleGene: X2019

Endothelial nitric oxide synthase gene polymorphisms and erectile dysfunction in chronic pain.

Ana Segura, Pura Ballester, Raquel Ajo, María-Del-Mar Inda, Antonio Urbano, Javier Muriel, Isabel Ochando, César Margarit, Emi Martinez, Ana M Peiró

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gene: X, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Ana SeguraAndrology Unit, University General Hospital of Alicante (HGUA), Alicante, Spain.
Pura BallesterNeuropharmacology on Pain Research Unit, Institute of Health and Biomedical Research of Alicante (ISABIAL-FISABIO), Alicante, Spain.
Raquel AjoNeuropharmacology on Pain Research Unit, Institute of Health and Biomedical Research of Alicante (ISABIAL-FISABIO), Alicante, Spain.
María-Del-Mar IndaNeuropharmacology on Pain Research Unit, Institute of Health and Biomedical Research of Alicante (ISABIAL-FISABIO), Alicante, Spain.
Antonio UrbanoGenetics Unit, Clínica Vistahermosa HLA-Hospital, Alicante, Spain.
Javier MurielNeuropharmacology on Pain Research Unit, Institute of Health and Biomedical Research of Alicante (ISABIAL-FISABIO), Alicante, Spain.
Isabel OchandoGenetics Unit, Clínica Vistahermosa HLA-Hospital, Alicante, Spain.
César MargaritNeuropharmacology on Pain Research Unit, Institute of Health and Biomedical Research of Alicante (ISABIAL-FISABIO), Alicante, Spain.
Emi MartinezPain Unit, HGUA, Alicante, Spain.
Ana M PeiróNeuropharmacology on Pain Research Unit, Institute of Health and Biomedical Research of Alicante (ISABIAL-FISABIO), Alicante, Spain.
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana · ESUniversitat de Miguel Hernández d'Elx · ESHospital General Universitario de Alicante Doctor Balmis · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate whether SUBJECT PATIENTS/

methodsThe study participants were Spaniard males with erectile dysfunction (ED) and chronic pain (

resultsA total of 69 patients required andrological treatment and 76% of them improved ED upon iPED5 (20%), testosterone (35%) or iPDE5/testosterone treatment (45%); being significantly better in T786C-CC patients. Multivariate regression analysis indicated that age, opioid daily dose and carriage of T786C-C allele influenced the risk and ED severity in Spaniard chronic pain patients.

conclusionT786C polymorphism at

Indexed as

BMI, body mass indexcGMP, 3′,5′-cyclic guanosine monophosphateChronic painCNP, chronic non-cancer painED, erectile dysfunctionEF, Erectile functioneNOS, endothelial nitric oxide synthaseeNOS geneErectile dysfunctionIIEF, International Index of Erectile FunctioniPDE5iPDE5, phosphodiesterase type 5 inhibitorsmSLQQ-QOL, modified Sexual Life Quality QuestionnaireNO, nitric oxidePharmacogeneticsT786CVAS, Visual analogue scale

Identifiers

PMID32550542
PMCPMC7285905
OpenAlexW2913611110

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.