Evidence map›Paper›PMID 32550227›Full record

ArticleBioMed research international2020

Adaptive Molecular Evolution of

Farmanullah, Seyed Mahdi Hosseini, Aixin Liang, Guohua Hua, Zia Ur Rehman, Hira Sajjad Talpur, Mohammad Salim, Saeed Ahmad, Adili Abulaiti, Momen Khan and 8 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 3 countries.

Farmanullah *Faculty of Veterinary and Animal Sciences, Department of Livestock Production, Lasbela University of Agriculture, Water and Marine Sciences, Uthal, Pakistan.ORCID https://orcid.org/0000-0003-1163-5004
Seyed Mahdi Hosseini *Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China.ORCID https://orcid.org/0000-0003-4255-7045
Aixin LiangKey Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Guohua HuaKey Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Zia Ur RehmanDepartment of Animal Health, Faculty of Animal Husbandry and Veterinary Sciences, The University of Agriculture Peshawar, Pakistan.ORCID https://orcid.org/0000-0002-4238-575X
Hira Sajjad TalpurDepartment of Animal Breeding and Genetics, Sindh Agriculture University, Tandojam, Pakistan.
Mohammad SalimDepartment of Forestry and Wildlife Management, The University of Haripur, Khyber Pakhtunkhwa, Pakistan.
Saeed AhmadInstitute of Biological Sciences, Sarhad University of Science and Information Technology, Peshawar, Khyber Pakhtunkhwa, Pakistan.
Adili AbulaitiKey Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Momen KhanLivestock and Dairy Development, Khyber Pakhtunkhwa, Pakistan.
Muhammad SafdarKey Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Ihsan Ullah KakarDepartment of CMS (FVAS), Lasbela University of Agriculture, Water and Marine Sciences, Uthal, Balochistan, Pakistan.
Zahoor AhmadAdaptive Research Program, Quetta, Pakistan.
Muhammad Zulfiqar AhmadGuangdong Provincial Key Laboratory of Plant Molecular Breeding, Guangdong Subcenter of National Center for Soybean Improvement, College of Agriculture, South China Agricultural University, Guangzhou 510642, Guangdong, China.
Ye TingzhuKey Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Nicola M SchreursAnimal Science, School of Agriculture and Environment, Massey University, Palmerston North, New Zealand.
Iqra BanoKey Laboratory of Henan Province for Drug Quality and Evaluation, Ministry of Education of China, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
Liguo YangKey Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China.ORCID https://orcid.org/0000-0002-0990-8694
Huazhong Agricultural University · CNGovernment of Khyber Pakhtunkhwa · PKLasbela University of Agriculture Water and Marine Science · PKMassey University · NZSarhad University of Science and Information Technology · PKSouth China Agricultural University · CNUniversity of Haripur · PKZhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The V-Akt Murine Thymoma Viral Oncogene Homolog 3 (AKT3) gene is of the serine/threonine-protein kinase family and influences the production of milk fats and cholesterol by acting on the sterol administrative area restricting protein (SREBP). The AKT3 gene is highly preserved in animals, and during lactation in cattle, its expression increases. The AKT3 gene is expressed in the digestive system, mammary gland, and immune cells. A phylogenetic investigation was performed to clarify the evolutionary role of AKT3, by maximum probability. The AKT3 gene sequence data of various mammalian species was evident even with animals undergoing breeding selection. From 39 mammalian species studied, there was a signal of positive diversifying selection with Hominidae at 13Q, 16G, 23R, 24P, 121P, 294K, 327V, 376L, 397K, 445T, and 471F among other codon sites of the AKT3 gene. These sites were codes for amino acids such as arginine, proline, lysine, and leucine indicating major roles for the function of immunological proteins, and in particular, the study highlighted the importance of changes in gene expression of AKT3 on immunity.

Indexed as

Evolution, MolecularProto-Oncogene Proteins c-aktAnimalsCattleHumansMammalsProtein Interaction MapsSelection, GeneticProto-Oncogene Proteins c-akt

Identifiers

PMID32550227
PMCPMC7256775
OpenAlexW3026310934

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.