ArticleJournal of medical biochemistry2020
Leukocytosis interference in clinical chemistry: Shall we still interpret test results without hematological data?
Article in Journal of medical biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Investigation and Causes of Spontaneous (Non-Diabetic) Hypoglycaemia in Adults: Pitfalls to Avoid.Diagnostics (Basel, Switzerland) · 2023Review
- Detection of preanalytical errors in arterial blood gas analysis.Biochemia medica · 2022Article
- The Stability of Blood Gas Parameters Depends on Leukocyte Counts.Annals of laboratory medicine · 2021Article
- Stability of hematological analytes during 48 hours storage at three temperatures using Cell-Dyn hematology analyzer.Journal of medical biochemistry · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExtreme leukocytosis is known to induce remarkable variations of some clinical chemistry tests, thus leading to possible clinical misinterpretation. This study aimed to define whether also moderate leukocytosis may influence the stability of glucose and blood gases.
methodsBlood samples are sent to the local laboratory through a pneumatic tube system. Clinical chemistry testing is routinely performed using Lithium-heparin tubes (for glucose) and heparin blood gases syringes (for blood gas analysis). Stability of glucose (in uncentrifuged blood tubes) and blood gases (in syringes) was hence evaluated in samples maintained at room temperature. Results were also analyzed in 2 subgroups of samples with different leukocyte counts, i.e., those with leukocytes <15 × 10
resultsAn accelerated decrease of pH was observed in blood gases syringes with leukocytosis (i.e., >15 × 10
conclusionsThe results of our study suggest that even modest leukocytosis (i.e., around 15 × 10
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