Evidence map›Paper›PMID 32549764›Full record

ArticleInternational journal of biological sciences2020

SETDB2 promoted breast cancer stem cell maintenance by interaction with and stabilization of ΔNp63α protein.

Liu Ying, Xie Fei, Li Jialun, Xiao Jianpeng, Wang Jie, Mei Zhaolin, Fan Hongjia, Fang Huan, Li Sha, Wu Qiuju and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. The dual role of p63 in cancer.Frontiers in oncology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 1 country.

Liu YingAnhui University of Science and Technology Affiliated Fengxian Hospital, Shanghai 201499, China.
Xie FeiDepartment of clinical laboratory, Taihe Hospital, Hubei University of Medicine, 29 South Renmin Road, Shiyan, Hubei 442000, China.
Li JialunShanghai University of Medicine & Health Sciences, Affiliated Sixth People's Hospital South Campus, Shanghai 201499, China.
Xiao JianpengDepartment of Laboratory Medicine & Central Laboratory, Southern Medical University Affiliated Fengxian Hospital, Shanghai 201499, China.
Wang JieDepartment of Laboratory Medicine & Central Laboratory, Southern Medical University Affiliated Fengxian Hospital, Shanghai 201499, China.
Mei ZhaolinAnhui University of Science and Technology Affiliated Fengxian Hospital, Shanghai 201499, China.
Fan HongjiaDepartment of Laboratory Medicine & Central Laboratory, Southern Medical University Affiliated Fengxian Hospital, Shanghai 201499, China.
Fang HuanAnhui University of Science and Technology Affiliated Fengxian Hospital, Shanghai 201499, China.
Li ShaAnhui University of Science and Technology Affiliated Fengxian Hospital, Shanghai 201499, China.
Wu QiujuShanghai University of Medicine & Health Sciences, Affiliated Sixth People's Hospital South Campus, Shanghai 201499, China.
Yuan LinShanghai University of Medicine & Health Sciences, Affiliated Sixth People's Hospital South Campus, Shanghai 201499, China.
Liu CuicuiShanghai University of Medicine & Health Sciences, Affiliated Sixth People's Hospital South Campus, Shanghai 201499, China.
Peng YouShanghai University of Medicine & Health Sciences, Affiliated Sixth People's Hospital South Campus, Shanghai 201499, China.
Zhao WeiweiShanghai University of Medicine & Health Sciences, Affiliated Sixth People's Hospital South Campus, Shanghai 201499, China.
Wang LuluShanghai University of Medicine & Health Sciences, Affiliated Sixth People's Hospital South Campus, Shanghai 201499, China.
Wong JieminShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Li JingDepartment of Laboratory Medicine & Central Laboratory, Southern Medical University Affiliated Fengxian Hospital, Shanghai 201499, China.
Feng JingDepartment of Laboratory Medicine & Central Laboratory, Southern Medical University Affiliated Fengxian Hospital, Shanghai 201499, China.
Shanghai University of Medicine and Health Sciences · CNAnhui University of Science and Technology · CNEast China Normal University · CNSouthern Medical University · CNHubei University of Medicine · CNShanghai Jiao Tong University · CNThird Affiliated Hospital of Southern Medical University · CN

Funding

EPA EP-C-15-001EPA EP-C-15-004
6 · The paper itself

Abstract

The histone H3K9 methyltransferase SETDB2 is involved in cell cycle dysregulation in acute leukemia and has oncogenic roles in gastric cancer. In our study, we found that SETDB2 plays essential roles in breast cancer stem cell maintenance. Depleted SETDB2 significantly decreased the breast cancer stem cell population and mammosphere formation

Indexed as

Breast NeoplasmsCell Line, TumorCycloheximideFemaleGene Expression Regulation, NeoplasticHedgehog ProteinsHistone-Lysine N-MethyltransferaseHumansLeupeptinsNeoplastic Stem CellsTranscription FactorsTumor Suppressor Proteinsbenzyloxycarbonylleucyl-leucyl-leucine aldehydeCycloheximideHedgehog ProteinsHistone-Lysine N-MethyltransferaseLeupeptinsSETDB2 protein, humanTP63 protein, humanTranscription FactorsTumor Suppressor ProteinsBreast cancer stem cellHedgehog pathwaySETDB2stabilityΔNp63α

Identifiers

PMID32549764
PMCPMC7294945
OpenAlexW3027690643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.