ArticleInternational journal of trichology
Evaluation of Systemic Oxidative Stress in Patients with Premature Canities and Correlation of Severity of Hair Graying with the Degree of Redox Imbalance.
Article in International journal of trichology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Autophagy and Premature Graying of Hair: The Role of LC3 as a Biomarker in a Case-Control Study.Dermatology practical & conceptual · 2025Article
- Gray Hair: From Preventive to Treatment.Clinical, cosmetic and investigational dermatology · 2025Review
- Magnitude and contributing factors responsible for premature greying of hair: A cross-sectional study.Bioinformation · 2025Article
- Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextPremature canities etiopathogenesis is unclear, and approach to its therapy remains arbitrary. Reactive oxygen species generated during melanin biosynthesis in anagen hair bulb have been implicated in melanocyte apoptosis and hair graying. Extraneous factors, namely environmental pollution, stressful lifestyle, may compound the melanogenesis-induced endogenous oxidative stress.
aimsWe aimed to investigate the role of systemic oxidative stress in causation of premature canities and its correlation with the severity of hair graying. SETTINGS AND
designThis was a tertiary care hospital-based cross-sectional study. MATERIALS AND
methodsConsecutive 50 patients with premature hair graying, aged <25 years, and 30 age and sex-matched healthy controls were recruited. Severity of premature canities was graded based on the total number of gray hair on the scalp. Redox status was evaluated in cases and controls, by malondialdehyde (MDA), reduced glutathione (rGSH), and superoxide dismutase (SOD) measurement in serum, by enzyme-linked immunosorbent assay.
resultsSerum MDA concentration, an oxidative stress marker, was significantly higher (
conclusionSystemic redox imbalance is present in premature canities patients, with the severity of hair graying varying in parallel to the degree of oxidative stress. Antioxidants supplementation is likely to yield therapeutic benefit in premature canities.
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