Evidence map›Paper›PMID 32549330›Full record

ArticleBiomolecules2020

MicroRNA Alterations in a Tg501 Mouse Model of Prion Disease.

Janne M Toivonen, David Sanz-Rubio, Óscar López-Pérez, Alba Marín-Moreno, Rosa Bolea, Rosario Osta, Juan J Badiola, Pilar Zaragoza, Juan-Carlos Espinosa, Juan-Maria Torres and 1 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Janne M ToivonenLaboratorio de Genética Bioquímica (LAGENBIO), Facultad de Veterinaria, University of Zaragoza, 50013 Zaragoza, Spain.ORCID 0000-0002-7243-1737
David Sanz-RubioLaboratorio de Genética Bioquímica (LAGENBIO), Facultad de Veterinaria, University of Zaragoza, 50013 Zaragoza, Spain.ORCID 0000-0002-5228-248X
Óscar López-PérezLaboratorio de Genética Bioquímica (LAGENBIO), Facultad de Veterinaria, University of Zaragoza, 50013 Zaragoza, Spain.ORCID 0000-0003-2454-2114
Alba Marín-MorenoCentro de Investigación en Sanidad Animal (CISA-INIA), 28130 Madrid, Spain.
Rosa BoleaInstituto de Investigación Sanitaria Aragón (IIS Aragón), University of Zaragoza, 50009 Zaragoza, Spain.
Rosario OstaLaboratorio de Genética Bioquímica (LAGENBIO), Facultad de Veterinaria, University of Zaragoza, 50013 Zaragoza, Spain.
Juan J BadiolaInstituto de Investigación Sanitaria Aragón (IIS Aragón), University of Zaragoza, 50009 Zaragoza, Spain.
Pilar ZaragozaLaboratorio de Genética Bioquímica (LAGENBIO), Facultad de Veterinaria, University of Zaragoza, 50013 Zaragoza, Spain.
Juan-Carlos EspinosaCentro de Investigación en Sanidad Animal (CISA-INIA), 28130 Madrid, Spain.
Juan-Maria TorresCentro de Investigación en Sanidad Animal (CISA-INIA), 28130 Madrid, Spain.ORCID 0000-0003-0443-9232
Inmaculada Martín-BurrielLaboratorio de Genética Bioquímica (LAGENBIO), Facultad de Veterinaria, University of Zaragoza, 50013 Zaragoza, Spain.ORCID 0000-0001-6016-4726
Universidad de Zaragoza · ESCentro de Investigación en Sanidad Animal

Funding

Government of Aragón co-financed with FEDER 2014-2020 "Construyendo Europa desde Aragón", and Centro de Investigación Biomédica en Red, Enfermedades Neurodegenerativas (CIBERNED) A19-17RInstituto de Salud Carlos III and Fondo Europeo de Desarrollo Regional (FEDER) "Una manera de hacer Europa" Grant PI17/00949Instituto Nacional de Investigación y Tecnología Agraria y Agroalimentaria INIA-FPI-SGIT-2015-02Ministerio de Ciencia e Innovación RTI2018-098711-B-I00Spain-France-Andorra Cooperation Program (POCTEFA), co-funded by the European Regional Development Fund (ERDF) EFA 148/16 REDPRIONSpanish Ministerio de Economía y Competitividad AGL2015-67945-PSpanish Ministerio de Economía y Competitividad AGL2016-78054-R
6 · The paper itself

Abstract

MicroRNAs (miRNAs) may contribute to the development and pathology of many neurodegenerative diseases, including prion diseases. They are also promising biomarker candidates due to their stability in body fluids. We investigated miRNA alterations in a Tg501 mouse model of prion diseases that expresses a transgene encoding the goat prion protein (

Indexed as

Disease Models, AnimalMice, TransgenicAnimalsGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksGoat DiseasesGoatsMiceMicroRNAsPrion DiseasesSequence Analysis, RNAMicroRNAsbiomarkersmicroRNAprion diseasesscrapie

Identifiers

PMID32549330
PMCPMC7355645
OpenAlexW3034343052

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.