Evidence map›Paper›PMID 32549326›Full record

ArticleNutrients2020

Aqueous Fraction from

Anas M A Alsayed, Bei Li Zhang, Pierre Bredeloux, Leslie Boudesocque-Delaye, Angèle Yu, Nicolas Peineau, Cécile Enguehard-Gueiffier, Elhadi M Ahmed, Côme Pasqualin, Véronique Maupoil

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Anas M A AlsayedEA 7349, Laboratoire Signalisation et Transports Ioniques Membranaires, Groupe Physiologie des Cellules Cardiaques et Vasculaires, Faculté de Pharmacie, Université de Tours, 31 avenue Monge, 37200 Tours, France.
Bei Li ZhangEA 7349, Laboratoire Signalisation et Transports Ioniques Membranaires, Groupe Physiologie des Cellules Cardiaques et Vasculaires, Faculté de Pharmacie, Université de Tours, 31 avenue Monge, 37200 Tours, France.
Pierre BredelouxEA 7349, Laboratoire Signalisation et Transports Ioniques Membranaires, Groupe Physiologie des Cellules Cardiaques et Vasculaires, Faculté de Pharmacie, Université de Tours, 31 avenue Monge, 37200 Tours, France.
Leslie Boudesocque-DelayeEA 7502 SIMBA-Laboratoire Synthèse et Isolement de Molécules BioActives, Université de Tours, Faculté de Pharmacie, 31 avenue Monge, 37200 Tours, France.
Angèle YuEA 7349, Laboratoire Signalisation et Transports Ioniques Membranaires, Groupe Physiologie des Cellules Cardiaques et Vasculaires, Faculté de Pharmacie, Université de Tours, 31 avenue Monge, 37200 Tours, France.
Nicolas PeineauEA 7349, Laboratoire Signalisation et Transports Ioniques Membranaires, Groupe Physiologie des Cellules Cardiaques et Vasculaires, Faculté de Pharmacie, Université de Tours, 31 avenue Monge, 37200 Tours, France.
Cécile Enguehard-GueiffierEA 7502 SIMBA-Laboratoire Synthèse et Isolement de Molécules BioActives, Université de Tours, Faculté de Pharmacie, 31 avenue Monge, 37200 Tours, France.
Elhadi M AhmedDepartment of Pharmacognosy, Faculty of Pharmacy, University of Gezira, Sudan, P.O. Box 20, Wad Medani 21111, Sudan.
Côme PasqualinEA 7349, Laboratoire Signalisation et Transports Ioniques Membranaires, Groupe Physiologie des Cellules Cardiaques et Vasculaires, Faculté de Pharmacie, Université de Tours, 31 avenue Monge, 37200 Tours, France.
Véronique MaupoilEA 7349, Laboratoire Signalisation et Transports Ioniques Membranaires, Groupe Physiologie des Cellules Cardiaques et Vasculaires, Faculté de Pharmacie, Université de Tours, 31 avenue Monge, 37200 Tours, France.
Université de Tours · FRUniversity of Gezira · SD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectives

methodsVascular effects of HS aqueous fraction (AF) on isolated MA rings, as well as its mechanisms of action, were assessed using the contractility and intracellular microelectrode technique. The patch clamp technique was used to evaluate the effect of HS AF on the L-type calcium current. Extraction and enrichment of AF were carried out using liquid-liquid extraction, and the yield was analyzed using HPLC.

resultsThe HS AF induced a concentration-dependent relaxant effect on MA rings of SHR (EC

conclusionThese results highlight that the antihypertensive effect of HS probably involves a vasorelaxant effect on small resistance arteries, which is endothelium independent. L-type calcium current reduction contributes to this effect. The results could also provide a link between the vasorelaxant effect and the bioactive compounds, especially anthocyanins.

Indexed as

AnimalsAntihypertensive AgentsCalcium ChannelsFlowersHibiscusHypertensionMaleMesenteric ArteriesPatch-Clamp TechniquesPlant ExtractsPotassium Channel BlockersPotassium ChannelsRatsRats, Inbred SHRRats, Inbred WKYVasodilator AgentsAntihypertensive AgentsCalcium ChannelsPlant ExtractsPotassium Channel BlockersPotassium ChannelsVasodilator AgentsanthocyaninsCa2+ currentHibiscus sabdariffahypertensionmesenteric arteryvasorelaxation

Identifiers

PMID32549326
PMCPMC7353181
OpenAlexW3035663549

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.